alzheimer’s disease (ad) is a neurodegenerative disorder and the most common form of dementia. almost 47 million people suffer from dementia worldwide. ad accounts for approximately 60%–80% of all dementia cases. three major pathologies characterize the disease: senile plaques, neurofibrillary tangles and inflammation. we review the literature on events contributing to the inflammation. those i...

A subcellular fraction enriched in twisted tubules was obtained by differential centrifugation of a homogenate of neurons isolated from areas of the brain with many neurofibrillary tangles from patients with Alzheimer's presenile-senile dementia. A unique protein (molecular weight 50,000 daltons) which does not co-migrate with either of the two tubulin monomers of the major neurofilament protei...

Neuropathologically, Alzheimer’s disease is characterized by the presence of extracellular deposits of amyloid-β peptides, intracellular neurofibrillary tangles and atrophy of the basal forebrain cholinergic neurons. The research of pathogenesis of Alzheimer’s disease inspirits potential clinical drugs for treatment. To block the progression of the disease, drugs under development have to inter...

In this short review, the link between aging and the onset of Alzheimer 's disease is discussed. It has been widely suggested that aging is the greatest risk factor for Alzheimer 's disease,in which a failure in the insulin signal-transduction pathway could occur with age and, thereby, the assembly of senile plaques and neurofibrillary tangles (two aberrant structures present in Alzheimer 's di...