نتایج جستجو برای: neuroendocrine tumours
تعداد نتایج: 49836 فیلتر نتایج به سال:
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and observe frequent mutations in chromatin-remodelling genes. Covalent histone modif...
Neuroendocrine tumours (NETs) are very rare diseases characterised by a high degree of histological and clinical heterogeneity. They can be silent (even producing some hormones) or clinically evident as a result of local growth and/or hormonal production. The diagnostic and therapeutic approach to patients with NETs should be multidisciplinary. A medical oncologist should coordinate a group of ...
Multiple endocrine neoplasia type 1 (MEN-1) is a rare autosomal-dominant disease. It is associated with a broad range of endocrine tumours, most frequently arising in the parathyroid glands, the pituitary and the pancreas. Most neuroendocrine tumours will be diagnosed in the pancreas as non-functioning neuroendocrine tumours or insulinomas. Forty-two percent of the patients will develop a gastr...
Endoscopic ultrasound (EUS) enables detection and localization of pancreatic neuroendocrine tumours. Even small tumours down to a diameter of 1-2 mm can be visualized. Since such small tumours usually cannot be detected by computed tomography (ct), magnetic resonance imaging (mri) and somatostatin receptor scintigraphy (srs), and experience with EUS imaging is limited, there is no clear evidenc...
Neuroendocrine tumours are characterised by the expression of high affinity binding sites for somatostatin. The detection of bronchial carcinoid tumours through scintigraphic imaging is described in two patients using the novel radiolabelled somatostatin analogue indium-111 pentetreotide. (Thorax 1994;49:284-286) Large numbers of high affinity somatostatin binding sites have been found on most ...
Epithelial cell adhesion molecule 1 (EpCAM) is an epithelial membrane glycoprotein, often used as a surrogate pan-epithelial marker. To compare the expression patterns of EpCAM and pankeratin antibody (CKpan), gold standard detection, tissue microarrays containing 11,053 samples from 101 different tumor types were analysed by immunohistochemistry. staining was detectable in 99 (82.5%) 120 tumou...
Here we review the pathologic features of a specialized tumor subset, collectively referred to as neuroendocrine tumors. These tumors arise almost anywhere in the body but many issues regarding their diagnosis and classification remain to be settled. Recent technical improvements, have increased the rate of detection, and have contributed to better diagnosis and classification of these tumors.
Edfeldt, K. 2014. Small Intestinal Neuroendocrine Tumours. Genetic and Epigenetic Studies and Novel Serum Biomarkers. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 975. 51 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8887-1. Small intestinal neuroendocrine tumours (SI-NETs) are rare, hormone producing and proliferate slowly. Patients usual...
Pancreatic neuroendocrine tumours (PTENs) are a heterogeneous group of tumours that develop from neuroendocrine cells of the pancreas [1]. Pancreatic neu-roendocrine tumours comprise a rare group of pancre-atic tumours and represent about 1–2% of all tumours developing within this organ [2]. The potential of neu-roendocrine cells to produce and secrete peptides and/ or biogenic amines affecting...
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