The objective of this paper is to present general considerations which should be kept in mind by clinicians in charge of women with vulvar diseases. Four representative vulvar dermatoses are described. Lichen simplex chronicus is a pathological condition related to chemical and mechanical irritant agents. Detrimental effects of these irritants, in the presence of other dermatoses, have to be co...

Just like allergic diseases (in particular the allergic diseases such as neurodermatitis), chronic inflammatory bowel diseases (Morbus Crohn and ulcerative colitis) are becoming more frequent by the day. They mainly occur in countries with high living standards such as North America or Western and Northern Europe. In both cases, statistics show a frequency of 2-5 cases per 100.000 inhabitants a...

OBJECTIVES Acupuncture is a form of Traditional Chinese Medicine that has been used to treat a broad range of medical conditions, including dermatologic disorders. This systematic review aims to synthesize the evidence on the use of acupuncture as a primary treatment modality for dermatologic conditions. METHODS A systematic search of MEDLINE, EMBASE, and the Cochrane Central Register was per...

ECZEMA may be defined as a particular type of catarrhal inflammation of the skin, manifesting itself as vesication, weeping, or thickening of the epidermis. It can be caused by substances reaching the skin from outside the body (contact eczema or dermatitis), the subsequent reaction resulting either from a simple primary irritant effect or from an allergic mechanism. Patch tests are applicable ...

vacious plant distributed across all of Korea and also cultivated in China. The root of Cynanchum paniculatum is used as a Chinese traditional medicine. Recently, the plants of genus Cynanchum of Asclepiadaceae, e.g. Cynanchum atratum, Cynanchum auriculatum and Cynanchum paniculatum, were studied for their anticancer and analgesic effects. In addition, Cynanchum paniculatum has been traditional...

Lichen simplex chronicus is a skin disease that mostly affects female patients, with a peak incidence between ages 35 and 50 years. On the scalp, it appears as a single or multiple oval lesions, showing scaling and hair shaft loss or breakage. An important dermoscopic feature of the disease are the “broom fibers.” Histopathology reveals the “hamburger” and the “gear wheel” signs. The aim of thi...

(Figure 2B). All specimens tested negative for microorganismsbyGrocott-Gomorimethenamine silver andacid-fast bacilli stains andwere not consistentwith lichen sclerosus or lichen simplex chronicus. Hydroxychloroquine therapy had previously failed for this patient, and she was therefore prescribed mycophenolate (500 mg, twice a day) by her pulmonologist. In addition, we recommended 3-times-daily ...

Multinucleated keratinocytes (also known as multinucleated epidermal giant cells) are a frequently overlooked histological finding in noninfectious inflammatory dermatoses. They are sometimes found in conditions characterized by chronic rubbing and pruritus, such as lichen simplex chronicus or prurigo nodularis, and may be a helpful clue in making the clinical diagnosis. This finding must be di...

BACKGROUND Hypertrophic lichen planus (HLP) classically involves shin and ankles and is characterized by hyperkeratotic plaques and nodules. Prurigo nodularis (PN) is a chronic neurodermatitis that presents with intensely pruritic nodules. Histopathology of HLP and PN demonstrate epidermal hyperplasia, hypergranulosis, and compact hyperkeratosis. The dermis shows vertically arranged collagen fi...