background: stem cells from human exfoliated deciduous teeth (shed) have the capability to differentiate into neural cells. neurotrophins including nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), and neurotrophin-4 (nt-4) have neurogenesis, neurotrophic, or neuroprotective effects and are expressed in developing teeth. the aim of this study was to mea...

the incidence of traumatic brain injury (tbi) are annually increasing, developed tissue engineering methods could represent the definite remedies for patients with strongly injured central nervous system and have a great effect in the public healthcare cost. the current clinical treatments in tbi display several limitations. furthermore, several therapies, coming from neural tissue engineering ...

proteomic approach Ming-Chu Tsai, Li-Fen Shen, Huai-Sheng Kuo, Henrich Cheng, Kin-Fu Chak 1 Institute of Biochemistry and Molecular Biology, National Yang-Ming University, School of Life Sciences, Taipei 11221, Taiwan, Republic of China 2 Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China 3 Cent...

The objective of this research was to determine the origin of the cholinergic neurons that populate the heart following ablation of the neural crest area, which normally gives rise to the cardiac ganglia. Using ablation of various areas of surface ectoderm--including neural crest migrating to the heart, nodose placode, and neural crest plus nodose placode--it was determined that regeneration of...

Regeneration of the retina in amphibians is initiated by the transdifferentiation of the retinal pigmented epithelium (RPE) into neural progenitors. A similar process occurs in the early embryonic chick, but the RPE soon loses this ability. The factors that limit the competence of RPE cells to regenerate neural retina are not understood; however, factors normally involved in the development of ...

Introduction: There are several spinal cord injury models available for studying axonal repair in vivo [1] however, these studies are restricted to functional or behavioural changes [2] or tissue level pathologic changes detectable by MRI [3] and by histology [4]. In vitro models that use dissociated neurons provide useful information about extrinsic factors and substrates that promote neural c...

spinal cord injury (sci) is a destructive event that often lead to permanent neurologic deficit. current clinical treatments are aimed at preventing secondary damage, promoting regeneration, and replacing destroyed spinal cord tissue, although effective treatments for sci remain limited. cell therapies for treating sci are promising therapy for replacing dead cells, neuroprotection and axon reg...

spinal cord injury (sci) in humans remains a devastating and incurable disorder. a very important obstacle in axonal regeneration after spinal cord injury is astroglial scaring. the use of self-assembling peptide nanofiber, a hydrogel mimicking extracellular matrix, has been suggested as a scaffold for spinal cord regeneration and inhibition of astrogliosis. however, neurogenesis potential of l...

Regeneration of the teleost retina following surgical extirpation of 25% to 100% of the neural retina was investigated in goldfish (Carrasius auratus) and sunfish (Lepomis cyanellus). The retina will regenerate following removal of up to 95% of the neural retina, however complete extirpation prevented regeneration. Visual sensitivity was assessed by examining components of the electroretinogram...