Among DNase I family members, only DNase gamma causes DNA fragmentation during apoptosis. However, the molecular basis for this functional feature of DNase gamma is poorly understood. Here we describe the identification of functional NLSs (nuclear localization signals) in DNase gamma and their roles in its apoptotic function. DNase gamma contains two NLSs: a classical bipartite-type NLS (NLS1) ...

introduction: gastric cancer remains the second most common cause of cancer-related deaths worldwide. in many malignancies like, lung and breast, multiple prognostic factors are known, such as mutations in ki-67, her-2/neu, p53. in this study, we evaluated immunohistochemical protein expression patterns of cell-cycle-regulators p53, proliferation marker ki-67, surface expression of cd44, her-2/...

These are notes for a talk in the MIT-NEU Graduate seminar on Hecke Algebras and Affine Hecke Algebras (AHAHA) held in Fall 2014. This talk is divided into three parts. In the first, we introduce the affine Hecke algebras and describe a useful basis for the algebra over the ground ring. We then give a complete description of the center of the affine Hecke algebra and prove Kato’s Theorem regard...

UNLABELLED The human epidermal growth factor receptor-2 (HER2/neu/ERBB2) is overexpressed in several cancer types. Although therapies targeting the HER2/neu protein result in inhibition of cell proliferation, the anticancer effect might be further optimized by limiting HER2/neu expression at the DNA level. Towards this aim, epigenetic editing was performed to suppress HER2/neu expression by ind...

The HER2/neu oncogene is overexpressed in a significant fraction of human tumors; such overexpression is thought to play a role in the aberrant proliferation of cancer cells. The effects of HER2/neu-specific phosphorothioate antisense oligodeoxyribonucleotides on HER2/neu expression, tumor cell proliferation, and activation of apoptotic cell death pathways have been examined. Antisense treatmen...

Introduction Heat shock protein 90 (HSP90) is required for the stability and activity of many proteins, including NEU/HER2 and its downstream proteins, which have key roles in cell growth and survival. Amplification and overexpression of NEU/HER2 proto-oncogene is observed in 25% of human breast cancers (1). 17-AAG is a novel anticancer drug that inhibits HSP90 leading to combinatorial degradat...