Objective(s):  The aim of this study was to evaluate the final outcome of nerve regeneration across the eggsell membrane (ESM) tube conduit in comparison with autograft. Materials and Methods: Thirty adult male rats (250-300 g) were randomized into (1) ESM conduit, (2) autograft, and (3) sham surgery groups. The eggs submerged in 5% acetic acid. The decalcifying membranes were cut into four pie...

Sciatic functional index (SFI) as a behavioral method was used to assess the functional recovery following experimentally-induced various injuries in the sciatic nerve, spinal cord, and brain. In the present study, the functional recovery after induction of injury in the sciatic nerve was investigated in rats using SFI. Twenty-four rats were divided into three groups including sham-operated (SS...

A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were u...

Background: Although peripheral nerves show capacity for regeneration after injury to a certain extent, the extent of regeneration is not remarkable. Previous studies have suggested that through the production of growth factors or extracellular matrix components, mesenchymal stem cells may enhance nerve regeneration.Objectives: In the present study, the therapeutic potenc...

BACKGROUND Root avulsion to all 5 roots of the brachial plexus is a common presentation and keeps a major reconstructive challenge. The contralateral C7 (CC7) nerve transfer has been used in treating brachial plexus avulsion injury (BPAI) since 1986. However, the effectiveness of the procedure remains a subject of controversy. The aim of this meta-analysis was to study surgical outcomes regardi...

The pudendal nerve innervates the external urethral sphincter (EUS) and is among the tissues injured during childbirth, which may lead to symptoms of stress urinary incontinence (SUI). To understand the mechanisms of injury and repair, urethral leak-point pressure (LPP) was measured 4 days, 2 wk, or 6 wk after bilateral pudendal nerve crush. Morphometric changes in the distal nerve and EUS were...

Recovery following peripheral nerve injuries is often incomplete. The gold standard treatment is surgical nerve repair performed immediately or shortly after injury. To date, there are no additional treatments that are used to enhance functional recovery. In this paper we outline two emerging applications of electrical stimulation to enhance nerve regeneration and functional recovery. The first...

background and aims:  using methods such as pulsed radiofrequency (prf) and nerve blocks are among the methods used in pain clinics to treat facet-originating low back pain. this study compares two methods of pulsed radiofrequency and facet joint block (fjb)regarding pain recovery and improving disability of patients suffering from facet-originating low back pain. material and method: 50 patien...

Autograft is gold standard treatment for peripheral nerve repair up to now. Eggshell membrane (ESM) as nerve guide channel effectively enhances nerve regeneration. Dimethyl sulphoxide (DMSO) has anti-inflammatory and anti-oxidant properties. The aim of this study was to evaluate the effect of DMSO+eggshell membrane guide channel on sciatic nerve regeneration in rats. Thirty two adult male rats ...

purpose: to evaluate the efficacy of subtenon injection of botulinum toxin a (dysport) in acute 6th nerve palsy. methods: this randomized clinical trial was performed on 28 patients with 6th nerve palsy of less than 3 months’ duration without history of extraocular muscles abnormality. ophthalmic examinations included visual acuity, degree of eye deviation, slitlamp biomicroscopy and funduscopy...