The conception of a degenerative form of nephritis as opposed to the common inflammatory form, whether justified or not, has been the source of many valuable observations on the clinical, chemical and histological aspects of the subject. The term nephrosis " was introduced by Aiiller(l) to indicate the purely degenerative form, and since the degeneration is frequently of the fatty type, the ter...

This study examined the contribution of changes in regulation of intestinal and hepatic cytochrome P450 3A (CYP3A) and multidrug resistance transporter 1 (Mdr1) to absorption of cyclosporine A (CsA) in a rat nephrosis model. Interleukin (IL)-6 was also measured. Puromycin aminonucleoside at a dose of 20 mg/100 g was administered intravenously. Tissue samples were dissected out from the upper an...

We have investigated the formation of fibrin, platelet aggregates, and subendothelial deposits in lipoid nephrosis. Fibrin formation was found in 10 cases of active lipoid nephrosis. Platelet aggregates were found in eight cases and subendothelial deposits in nine. Fibrin and platelets were also found in cases of nephrotic syndrome due to other causes, and in glomerulonephritis. Fibrin was gene...

Patients with lipemic nephrosis, cardiac failure, and hepatic cirrhosis frequently accumulate an excess of extracellular fluid, distributed in a pattern characteristic of the underlying disease. These patients commonly have a marked impairment of sodium excretion, while glomerular filtration may be low, normal, or even increased (1-4). This impairment of sodium excretion suggested the presence ...

Recent studies of the nephrotic kidney have implicated the glomerulus as the primary anatomic site of injury. Using the electron microscope, Farquhar, Vernier and Good (1) and other investigators have demonstrated that the most consistent and striking alteration is a lesion in the foot process of the glomerular epithelial cell. Hjelt, Stjernvall and Hallman (2), in a study of congenital nephros...

Acute mercurial nephrosis in the rabbit is not associated with a decrease of glomerular circulation.