GVHD and tumor relapse are fundamental problems in allogeneic HSCT. Recent research has linked neovascularization to GVHD, tumor growth, and graft-versus-tumor (GVT) activity. Damage of the endothelium by the conditioning regimen provides the initiation stimulus for recruitment of donor-derived endothelial cells and their progenitors. During the early inflammatory phase of GVHD there is conside...

Purpose Vascular endothelial growth factor (VEGF) is a principal mediator of pathological ocular neovascularization, which is the leading cause of blindness in various ocular diseases. As Src, a non-receptor tyrosine kinase, has been implicated as one of the major signaling molecules in VEGF-mediated neovascularization, the present study aimed to investigate whether dasatinib, a potent Src kina...

BACKGROUND Plaque neovascularization accompanies local inflammation and critically contributes to plaque instability. Correct identification of intraplaque neovascularization by contrast-enhanced ultrasound (CEUS) may provide an additional risk marker in carotid stenosis. This pilot study investigates the correlation between histological evaluation of carotid plaque specimens and pre-surgery CE...

Background: Herbal ingredients that can be used to reduce wound healing on the skin are administration of bioactive compounds from gemitir flowers (Tagetes erecta L) as an anti-inflammatory and antioxidant. This study prove oral extract increases number neovascularization, fibroblast cell epithelialization in male Wistar strains rats. Method: research is anexperimental with a randomized posttes...

Introduction: To study the unfavorable outcomes and regression after neovascularization treatment for non-type 1 retinopathy of prematurity (ROP) in a tertiary care facility Thailand. Methods: A retrospective was done all infants undergoing screening ROP at referral center between July 2018 June 2021 with follow-up 60 weeks postmenstrual ages (PMA). The measured were outcomes, including macula ...

A 60-year-old male patient admitted to our clinic with complaints of decreased vision, nyctalopia, and metamorphopsia in both eyes, mainly the left eye. The best-corrected visual acuity was determined as 20/25 on right 20/200 eye Snellen chart. Anterior segment examination normal. Fundus revealed chorioretinal atrophic areas bone spicules around all vascular arcades eyes. Optical coherence tomo...

Patients with Calreticulin ( CALR) mutation positive essential thrombocythemia are often thought of as having a “low-risk” thrombotic complications. This report examines case patient CALR-mutation presenting peripheral retinal ischemia and subsequent neovascularization. had 2-year documented history maximum platelet count over 800,000 cells/µL. Fluorescein angiogram showed significant leakage i...

A 62-year-old man was admitted after recurrent transient left-sided weakness and sensory loss. Ultrasound (US) examination revealed a 70% narrowing of the right proximal internal carotid artery (ICA). Contrast-enhanced US suggested plaque neovascularization (figure, A). Carotid endarterectomy of the right ICA was performed. Immunohistochemistry of the specimen showed, corresponding to the US fi...

Peripheral blood of adult species contains endothelial progenitor cells (EPCs) that participate in neovascularization, consistent with postnatal vasculogenesis. EPCs can be isolated not only from peripheral blood but also from bone marrow and human umbilical cord blood. In vitro culture-expanded EPCs participate in endothelial network formation (capillary formation) in vitro, and transplanted E...