Populations from seven pairs of neoplastic and nonneoplastic cell lines of common origin were compared for evidence of a change in morphotogical parameters accompanying neoplastic transformation. Projected cytoplasmic area, projected nuclear area, cell dry mass, nuclear dry mass, whole-cell absorption at 265 nm, and nuclear absorption at 265 nm were determined. Neoplastic transformation was con...

A variety of heterologous mammalian cells were inoculated into nude mice and scored for tumorigenicity. The cells tested were from primary cell cultures, established cell lines of neoplastic origin, established cell lines of nontumor origin, and primary cell cultures transformed by oncogenic viruses. Regardless of the animal species of origin, every cell line that was tumorigenic in some other ...

When hamster embryonic skin and s.c. tissue cells were infected in vitro with small-plaque (SP) and large-plaque (LP) variants of chicken embryo lethal orphan virus, neoplastic cell lines were established. The SP cell line was made up of pleomorphic cells, whereas the LP cell line consisted of cells that were spindled to oval. The SP but not the LP cell line revealed virus-specific, intranuclea...

When hamster embryonic skin and s.c. tissue cells were infected in vitro with small-plaque (SP) and large-plaque (LP) variants of chicken embryo lethal orphan virus, neoplastic cell lines were established. The SP cell line was made up of pleomorphic cells, whereas the LP cell line consisted of cells that were spindled to oval. The SP but not the LP cell line revealed virus-specific, intranuclea...

We have studied the expression of gelatinase A, gelatinase B, interstitial collagenase, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in reactive lymphoid cells, as well as in a series of cell lines derived from neoplasms of B- and T-cell lineage. Using both Northern blot analysis and zymography, gelatinase B activity was detected by zymography in two Burkitt cell lines and in a ton...

The role of the neurohypophyseal peptide oxytocin (OT) and its receptor (OTR) in the breast has been described mainly in relation to breast feeding or to neoplastic growth regulation. We demonstrate here the presence of OT synthesis within the breast under both physiological and neoplastic conditions. In order to clarify whether normal epithelial and myoepithelial cells could synthesize OT, the...

the neoplastic niche comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. these niches are important for both the maintenance of cancer stem cells and the induction of neoplastic cells survival and proliferation. each niche contains a population of tumor stem cells supported by a closely associated vascular bed compri...

The search for alternative and effective therapies to fight cancer is one of the main goals pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. goal this study was synthesize evaluate bioactivity different ILs coupled active ingredient (API) valproate (VPA) an agent. toxicity prepared evaluated by MTT cell metabolic assa...

The molecular basis of pancreatic cancer is not understood. Previous attempts to determine the specific genes expressed in pancreatic cancer have been hampered by similarities between adenocarcinoma and chronic pancreatitis. In the current study, microarrays (Affymetrix) were used to profile gene expression in pancreatic adenocarcinoma (10), pancreatic cancer cell lines (7), chronic pancreatiti...