Abstract YAP1 is a transcriptional co-activator and oncogene under the control of Hippo Signaling Pathway. Functional inactivation Pathway tumor suppressors, including NF2, are frequent events in human cancers. Meningiomas most common primary brain tumors, large percentage exhibit heterozygous loss chromosome 22 (harboring NF2 gene) functional remaining gene copy, implicating oncogenic YAP acti...

Although the natural host of the Rous sarcoma virus (RSV) is the chicken, many strains of the virus have induced tumors in various mammals. Recently, a New World monkey, the marmoset (Saquinus sp.), was added to the list of animals susceptible to RSV oncogenesis (1). This report deals with a unique membranous cytoplasmic structure found in cells from two intracerebral and four subcutaneous tumo...

Xenograft intracerebral glioma models have been developed in normal mice by growing the rat C6 glioma in either adult or neonatal mouse brains. Using this tumor line it was possible to grow discrete intracerebral gliomas in either CBA or AKR adult mice or neonatal mice. The size of the tumor mass and length of survival was directly related to the number of tumor cells injected and the time afte...

Ultrasound prenatal examination enables one to assess the facial skeleton and the neck from the first weeks of gestation. Cervicofacial tumors detected via prenatal ultrasound are very rarely reported fetal pathologies. They include cystic hygromas, teratomas, epulides, vascular tumors, and thyroid tumors. The tumor category, its location and vascularization pattern allow one to accurately esta...

The BrafV637E mutation is frequently reported in mouse hepatic tumors, depending on the mouse strain, and corresponds to the human BrafV600E mutation. In this study, we detected the BrafV637E mutation by whole-exome analysis in 4/4 hepatic tumors induced by neonatal treatment with diethylnitrosamine (DEN) in male B6C3F1 mice. We also detected the BrafV637E mutation in 54/63 (85.7%) hepatic lesi...

The incidence of fetal tumors has been increased due to generalization of prenatal evaluation and improvement of imaging techniques. The early detection of a fetal tumor and understanding of its imaging features are very important for fetal, maternal, and neonatal care. Ultrasonography is usually used for the detection and differential diagnosis of fetal tumors, and magnetic resonance imaging i...

induced tumors in experimental animals (16, 21, 24). Nevertheless, there are some exceptions to this generalization. The effect of neonatal thymectomy on the incidence of viral-induced leukemias in mice is inhibitory (17). Immuno depression also inhibits the development of tumors of the mouse mammary gland induced by the MTV. There have been several reports that neonatal thymectomy decreases ma...

Hepatocellular carcinoma develops in either chronically injured or seemingly intact livers. To explore the tumorigenic mechanisms underlying these different conditions, we compared the mRNA expression profiles of mouse hepatocellular tumors induced by the repeated injection of CCl4 or a single diethylnitrosamine (DEN) injection using a cDNA microarray. We identified tumor-associated genes that ...