Imipenem, the first carbapenem discovered, was developed more than two decades ago in response to an unmet need for a highly potent, broad-spectrum antimicrobial agent with a strong safety profile. It has since been used to treat more than 26 million patients. In an era where antibiotic use has driven antibiotic resistance, choosing appropriate initial therapy for serious infection is critical....

Western anthropology, based on the belief of dualism of body and mind, has unconsciously but profoundly influenced the basic approach to medicine for centuries. This separation of body and mind has become greater since the day of Decartes. Medical care has thus focused more on disease than illness, pain rather than suffering. New medical technologies bring new hopes of cure, but fail to allevia...

The 21st century has witnessed vast amounts of research into blended learning since the conception of online learning formed the possibility of blended learning in the early 1990s. The theme of this paper is blended learning in mainstream disciplinary communities. In particular, the paper reports on findings from the last two decades which looked at origination, development and future of blende...

Circadian rhythms coordinate our physiology at a fundamental level. Over the last 20 years, we have witnessed a paradigm shift in our perception of what the clocks driving such rhythms actually are, moving from 'black boxes' to talking about autoregulatory transcriptional/post-translational feedback loops with identified molecular components. We also now know that the pacemaker of the suprachia...

Two decades of OH variability as inferred by an inversion of atmospheric transport and chemistry of methyl chloroform P. Bousquet, D. A. Hauglustaine, P. Peylin, C. Carouge, and P. Ciais Laboratoire des Sciences du Climat et de l’Environnement (LSCE), Gif sur Yvette, France Université de Versailles Saint Quentin en Yvelines (UVSQ), Versailles, France Laboratoire de Biogéochimie des milieux cont...

A bstract We study some aspects of the de Sitter version Jackiw-Teitelboim gravity. Though we do not have propagating gravitons, a boundary mode when compute observables with fixed dilaton and metric at boundary. no-boundary wavefunctions probability measures to all orders in perturbation theory. also discuss contributions from different topologies, borrowing recent results by Saad, Shenker Sta...