Ca(+) sparklets are subcellular Ca(2+) signals produced by the opening of sarcolemmal L-type Ca(2+) channels. Ca(2+) sparklet activity varies within the sarcolemma of arterial myocytes. In this study, we examined the relationship between Ca(2+) sparklet activity and sarcoplasmic reticulum (SR) Ca(2+) accumulation and release in cerebral arterial myocytes. Our data indicate that the SR is a vast...

We present theorems and an algorithm to find optimal or near-optimal “stochastic resonance” (SR) noise benefits for Neyman-Pearson hypothesis testing and for more general inequality-constrained signal detection problems. The optimal SR noise distribution is just the randomization of two noise realizations when the optimal noise exists for a single inequality constraint on the average cost. The ...

Grain boundary and local structure of Sr-doped Li-excess garnet Li7+xLa3−xSrxZr2O12 (Sr-doped LLZO) with enhanced Li-ion conductivity were examined in this study. Cross-sectional observation by scanning electron microscopy (SEM) time-of-flight secondary ion mass spectrometry (TOF-SIMS) revealed that the formation grain is suppressed addition Sr to LLZO. Local structural analysis on La Zr sites ...

In view of finding a new gamma-aminobutyric acid (GABA) receptor ligand we synthesized an arylaminopyridazine derivative of GABA, SR 95103 [2-(carboxy-3'-propyl)-3-amino-4-methyl-6-phenylpyridazinium chloride]. SR 95103 displaced [3H]GABA from rat brain membranes with an apparent Ki of 2.2 microM and a Hill number near 1.0. SR 95103 (1-100 microM) antagonized the GABA-mediated enhancement of [3...

Effectively addressing marijuana trade is aided by understanding marijuana geographic sources. We analyzed the (87)Sr/(86)Sr of marijuana samples grown in 79 counties across the United States to determine if a primary geologic signal is retained in marijuana, which could therefore be useful for geographic sourcing. The marijuana results were compared with modeled bedrock (87)Sr/(86)Sr values ba...

Monopolar resonance is of fundamental importance in the acoustic field. Here, we present the realization of a monopolar resonance that goes beyond the concept of Helmholtz resonators. The balloon-like soft resonator (SR) oscillates omnidirectionally and radiates from all parts of its spherical surface, eliminating the need for a hard wall for the cavity and baffle effects. For airborne sound, s...

Isometric force and 45Ca loss from fiber to bath were measured simultaneously in skinned fibers from frog muscle at 19 degrees C. In unstimulated fibers, 45Ca efflux from the sarcoplasmic reticulum (SR) was very slow, with little or no dependence on EGTA (0.1-5 mM) or Mg++ (20 micrometer-1.3 mM). Stimulation by high [Cl] at 0.11 mM Mg++ caused rapid force transients (duration approximately 10 s...

We used the FUSE (Far Ultraviolet Spectroscopic Explorer) satellite to observe O VI emission along two sightlines towards the edge of the interaction zone (IZ) between the Loop I superbubble and the Local Bubble. One sightline was chosen because material in the interaction zone blocks distant X-ray emission, and should thus do the same for non-local O VI emission. We measured an O VI intensity ...

Physiological studies require sensitive tools to directly quantify transport kinetics in the cell/tissue spatial domain under physiological conditions. Although biosensors are capable of measuring concentration, their applications in physiological studies are limited due to the relatively low sensitivity, excessive drift/noise, and inability to quantify analyte transport. Nanomaterials signific...

Alkaline-earth metallic dopant can improve the performance of anatase TiO2 in photocatalysis and solar cells. Aiming to understand doping mechanisms, the dopant formation energies, electronic structures, and optical properties for Be, Mg, Ca, Sr, and Ba doped anatase TiO2 are investigated by using density functional theory calculations with the HSE06 and PBE functionals. By combining our result...