نتایج جستجو برای: ncx3

تعداد نتایج: 85  

Journal: :Journal of immunology 2005
Eduardo Aneiros Stephan Philipp Annette Lis Marc Freichel Adolfo Cavalié

Mast cells rely on Ca(2+) signaling to initiate activation programs leading to release of proinflammatory mediators. The interplay between Ca(2+) release from internal stores and Ca(2+) entry through store-operated Ca(2+) channels has been extensively studied. Using rat basophilic leukemia (RBL) mast cells and murine bone marrow-derived mast cells, we examine the role of Na(+)/Ca(2+) exchangers...

Journal: :BioTechniques 2002
Swamy K Polumuri Abdul Ruknudin Dan H Schulze

RNase H was originally described as an enzyme that specifically degrades RNA in an RNA:DNA hybrid and is inactive on ssor dsRNAs and DNAs alone (2). RNase H treatment is recommended during cDNA preparation because the RNase H activity, originally present in reverse transcriptases, has been removed in some cloned enzymes. These modified enzymes yield more cDNA, so they are now more routinely use...

Journal: :American journal of physiology. Cell physiology 2011
Nicole Heise Ekaterina Shumilina Meerim K Nurbaeva Evi Schmid Kalina Szteyn Wenting Yang Nguyen Thi Xuan Kan Wang Irina M Zemtsova Michael Duszenko Florian Lang

Ca(+)-dependent signaling regulates the function of dendritic cells (DCs), antigen-presenting cells linking innate and adaptive immunity. The activity of DCs is suppressed by glucocorticoids, potent immunosuppressive hormones. The present study explored whether the glucocorticoid dexamethasone influences the cytosolic Ca(2+) concentration ([Ca(2+)](i)) in DCs. To this end, DCs were isolated fro...

2008
Neil Venn Lee P. Haynes Robert D. Burgoyne

The KChIPs (K+ channel-interacting proteins) are members of the NCS (neuronal calcium sensor) protein family of Ca2+-binding proteins. It is unclear to what extent the KChIPs have distinct functions although they all interact with Kv4 K+ channels. KChIP3 has also been shown to repress transcription of specific genes via binding to DRE (downstream regulatory element) motifs and all KChIPs may sh...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Nicole N Scheff Michael S Gold

Persistent inflammation results in an increase in the amplitude and duration of depolarization-evoked Ca(2+) transients in putative nociceptive afferents. Previous data indicated that these changes were the result of neither increased neuronal excitability nor an increase in the amplitude of depolarization. Subsequent data also ruled out an increase in voltage-gated Ca(2+) currents and recruitm...

Journal: :Epilepsia 2004
Susan O M Ketelaars Jan A Gorter Eleonora Aronica Wytse J Wadman

PURPOSE The plasma membrane Ca2+ -adenosine triphosphatase (ATPase) (PMCA) and (potassium-dependent) sodium-calcium exchange [NC(K)X] represent two main calcium-extrusion mechanisms that are important for the restoration of [Ca2+]i levels after electrical activity. We investigated whether the expression of these calcium-extrusion proteins is altered in the course of epileptogenesis. METHODS H...

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