BACKGROUND The risk of neural tube defects (NTDs) is significantly reduced by supplemental folic acid. NTD risk may be associated with impaired absorption of polyglutamyl folate, the primary form of naturally occurring food folate, and of folic acid in supplements or fortified food. Stable-isotope methods provide the specificity needed to test this hypothesis. OBJECTIVE We determined whether ...

in 2007, research was carried out to determine the type and amount of asbestos fibers in a croatian factory with a long history of making asbestos-containing products.since the 1970s, asbestos fibres have been considered carcinogenic in humans i.e as a known cancer-causing agent. in the environment, asbestos fibres are inactive and naturally resist biodegradation. in time, fibres can only be gr...

The study of asbestos immunotoxicity is generally applied toward understanding the mechanisms that lead to its infamous outcomes, mesothelioma and asbestosis, rather than as an outcome itself. However, emerging evidence suggests that asbestos exposure has critical inflammatory and autoimmune effects. Although crystalline silica is broadly accepted as an exposure trigger for systemic autoimmune ...

Asbestos-related diffuse pleural thickening (DPT), or extensive fibrosis of the visceral pleura secondary to asbestos exposure, is increasingly common due to the large number of workers previously exposed to asbestos. It may coexist with asbestos related pleural plaques but has a distinctly different pathology. The pathogenesis of this condition as distinct from pleural plaques is gradually bec...

Asbestos is a generic term for a group of six naturally-occurring, fibrous silicate minerals that have been widely used in commercial products. These minerals are more commonly found in nonfibrous forms that are not asbestos. Asbestos minerals fall into two groups or classes, serpentine asbestos and amphibole asbestos. Chrysotile, a serpentine asbestos, possesses relatively long and flexible cr...

BACKGROUND Total folate intake includes naturally occurring food folate and folic acid from fortified foods and dietary supplements. Recent reports have focused on total folate intakes of persons aged > or =14 y. Information on total folate intakes of young children, however, is limited. OBJECTIVE The objective was to compute total folate and total folic acid intakes of US children aged 1-13 ...

Asbestos is a ubiquitous naturally occurring fiber causing multiple cancers and fibroproliferativedisease. The mechanisms of epithelial cell hyperplasia, a hallmark of the initiation of lung cancers by asbestos, have been unclear. We demonstrate here that mice expressing a dominant-negative mutant epidermal growth factor receptor (EGFR) under the control of the human lung surfactant protein-C p...