Objectives: The natural origin of medicinal plants does not guaranteed their safety, as there are no sufficient studies on the safety, efficacy and toxicity to support their beneficial claims. Hence, this study aimed at investigating the oral acute toxicity of Adansonia digitata L. fruit shell extract on mice. Methods: Maceration method was employed for the extraction of Adansonia digitata fru...

Clinical cancer chemoprevention started by studying natural agents presumed to be virtually free of toxicity. Beginning with these agents, however, the history of the major cancer chemoprevention trials has shown that evaluating adverse effects is every bit as important as evaluating preventive efficacy. Clinical trials have taught us invaluable lessons about the nature of serious toxicity in c...

stachys lavandulifolia is used as the herbal tea and its wide and potent medical effects have been reported for the extract in animal studies. this study aimed to find the safety profile of the extract to find the appropriate doses for further human studies. the aerial parts of the plant were air-dried and the hydroalcoholic extract was obtained and concentrated by percolation method with 140 m...

Decaleside II, a novel trisaccharide isolated from the edible roots of Decalepis hamiltonii, belongs to a new class of natural insecticides. We have evaluated the mammalian safety of Decaleside II in the laboratory mouse. Our results on acute and sub acute toxicity study suggest that Decaleside II is not toxic to the laboratory mice as there were no symptoms of toxicity or mortality up to 2400 ...

Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity and mortality secondary to hepatic failure. Overdose of APAP depletes the hepatic glutathione (GSH) rapidly, and the metabolic intermediate leads to hepatocellular death. This article reviews the mechanisms of hepatotoxici...

abstract background and objective: iranian traditional medicine (itm) has a long history in the prevention and treatment of diseases. clinical uses, side effects, and toxic effects of many singular and compounds were known to scientists of itm and articular books on toxicology and detoxification of drugs has been written by scientists, but their measurement tools to evaluate chronic toxicity of...