Background: Sri Lanka became a signatory to the WHO Framework Convention on Tobacco Control in September 2003 and ratified in November 2003. Aiming to reduce tobacco burden in Sri Lanka, National Authority on Tobacco and Alcohol Act [NATA] No. 27 was authorized in 2006. The objective of this study was to assess the behavioral changes related to tobacco use among adolescents and young adults fol...

We found that the heat shock protein 90 (Hsp90) chaperone system of the yeast Saccharomyces cerevisiae is greatly impaired in naa10Δ cells, which lack the NatA Nα-terminal acetylase (Nt-acetylase) and therefore cannot N-terminally acetylate a majority of normally N-terminally acetylated proteins, including Hsp90 and most of its cochaperones. Chk1, a mitotic checkpoint kinase and a client of Hsp...

Nod-like receptors (NLRs) serve as immune receptors in plants and animals. The stability of NLRs is tightly regulated, though its mechanism is not well understood. Here, we show the crucial impact of N-terminal acetylation on the turnover of one plant NLR, Suppressor of NPR1, Constitutive 1 (SNC1), in Arabidopsis thaliana. Genetic and biochemical analyses of SNC1 uncovered its multilayered regu...

Nα-acetyltransferases (Nats) possess a wide range of important biological functions. Their structures can vary according to the first two residues of their substrate. However, the mechanisms of substrate recognition and catalysis of Nats are elusive. Here, we present two structure of Sulfolobus solfataricus Ard1 (SsArd1), a member of the NatA family, at 2.13 and 1.84 Å. Both structures contain ...

N-terminal acetylation (NTA) is one of the most abundant protein modifications known, and the N-terminal acetyltransferase (NAT) machinery is conserved throughout all Eukarya. Over the past 50 years, the function of NTA has begun to be slowly elucidated, and this includes the modulation of protein-protein interaction, protein-stability, protein function, and protein targeting to specific cellul...

Nata de coco adalah makanan fungsional yang mengandung fiber. merupakan produk fermentasi bakteri Acetobacter xylinum ditumbuhkan pada media cair seperti air kelapa. Selain dari kelapa, mikroba juga memerlukan nutrisi tambahan yaitu carbon dan nitroge untuk pertumbuhannya dilakukan dalam proses fermentasi. Selama ini penambahan sumber nitrogen dengan menggunakan urea ZA digunakan pupuk pertania...

The effects of transcranial magnetic stimulation (TMS), natalizumab (nata), dimethyl fumarate (DMF) and dexamethasone (DEX) on clinical score and oxidative stress produced by a single dose of myelin oligodendrocyte glycoprotein (MOG) in tail of Dark Agouti rats was studied. TMS (60Hz and 0.7 mT), nata (5mg/kg), DMF (15mg/kg) and DEX (300μg/kg) was applied for 21 after the administration of MOG ...

Nata de mushroom is one of the products produced by fermenting boiled water white oyster mushrooms. White has a high carbohydrate content about 57.6%-81.8% dry weight and 86.6%. So that it can be used in manufacture nata mushrooms with addition red dragon fruit peel extract. The purpose this study was to determine organoleptic chemical characteristics mushroom. This research uses descriptive qu...

background: sri lanka became a signatory to the who framework convention on tobacco control in september 2003 and ratified in november 2003. aiming to reduce tobacco burden in sri lanka, national authority on tobacco and alcohol act [nata] no. 27 was authorized in 2006. the objective of this study was to assess the behavioral changes related to tobacco use among adolescents and young adults fol...