Cancer stem cells are regarded as the cause of tumour formation and recurrence in nasopharyngeal carcinoma (NPC). However, ideal surface markers for stem cells in NPC remain unidentified. In the present study, we investigated the expression of CD133, Nanog and Sox2 in the nasopharyngeal carcinoma cell line CNE2 and primarily cultured NPC cells using immunofluorescence or flow cytometry. A cell ...

introduction: nasopharyngeal carcinoma (npc) is a common cancer in the north-east region of india. though the role of environmental contributors of npc in the north-eastern part of india is firmly established, ebv as an etiological agent in the region remains unexplored. material and methods: fifty-one patients, who presented at the department of ent, neigrihms and were confirmed as npc upon hi...

OBJECTIVES Nasopharyngeal carcinoma is a unique tumour which is endemic in Southern China including Hong Kong. While the treatment results for primary cancer has been encouraging, management of persistent or recurrent tumours has been challenging. Compared to other surgical approaches, the maxillary swing operation provides spacious access to the bilateral nasopharynx and the ipsilateral paraph...

background:   primary bone lymphoma or non-hodgkin lymphoma of bone is a rare disease. there are only a few case series of stage ie of this condition in medical literature. the aim of this study is to determine the rate of survival   for stage ie after combined modality treatment, the rate of local recurrence, and the results of limb salvage in cases   of local recurrence.     methods:   we col...

Nasopharyngeal carcinoma is a common malignancy in Southern China. After radiotherapy and chemotherapy, a considerable proportion of patients with nasopharyngeal carcinoma suffered tumor relapse and metastasis. Cancer stem cells (CSC) have been shown with resistance against therapies and thus considered as the initiator of recurrence and metastasis in tumors, where the antiapoptotic property of...

BACKGROUND The purpose of this study was to evaluate the use of transoral nasopharyngeal brush biopsies and quantitative polymerase chain reaction (qPCR) Epstein-Barr virus (EBV) DNA detection system in surveillance of local recurrence of nasopharyngeal carcinoma (NPC). METHODS A prospective cohort study was performed to compare the nasopharyngeal epithelial EBV DNA levels of patients with re...

OBJECTIVE To present our experience in head and neck cancer, and the development of our own local electronic Makkah Head and Neck Database. METHODS A prospective collection of cases was conducted between October 2007 and November 2008 of patients diagnosed with head and neck cancer within the Department of Otolaryngology, Head and Neck Surgery at Al-Noor Specialist Hospital, Makkah, Kingdom o...

OBJECTIVE The objective of the study was to evaluate locoregional control after intensity-modulated radiotherapy for nasopharyngeal cancer using a target definition along with anatomical boundaries. METHODS Forty patients with biopsy-proven squamous cell or non-keratinizing carcinoma of the nasopharynx who underwent intensity-modulated radiotherapy between April 2006 and November 2009 were re...

Nasopharyngeal carcinoma (NPC) is a special type of head and neck cancer with a widely variable geographical variation in incidence. The central location of the tumor inside the head coupled with the radiosensitivity of the tumor to radiation made radiation therapy the first choice in primary treatment of NPC. Advances in radiotherapy and chemotherapy have markedly improved the local control of...