نتایج جستجو برای: narcoleptic drug
تعداد نتایج: 590028 فیلتر نتایج به سال:
Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy, direct onsets of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of orexins, neuropeptides that promote wakefulness largely via activation of histamine (HA) pathways. The hypothesis that the orexin defect can be circumvented by enhancing HA release was explored in narcoleptic mice and patients u...
one of the applications of nanotechnology is use of carbon nanotubes for the targeted delivery of drug molecules. to demonstrate the physical and chemical properties of biomolecules and identify new material of drug properties, the interaction of carbon nanotubes (cnts) with biomolecules is a subject of many investigations. cnts is a synthetic compound with extraordinary mechanical, thermal, el...
A multiple sleep latency test (MSLT) with occurrence of onset REM periods (SOREMP) is considered one the central diagnostic criteria for narcolepsy according to International Classification Sleep Disorders, but its sensitivity and specificity have been questioned. This study aims describe MSLT polysomnography (PSG) findings, including frequency distribution SOREMP during day, in a large cohort ...
OBJECTIVE To determine the role of CSF hypocretin-1 in narcolepsy with and without cataplexy, Kleine-Levin syndrome (KLS), idiopathic and other hypersomnias, and several neurological conditions. PATIENTS 26 narcoleptic patients with cataplexy, 9 narcoleptic patients without cataplexy, 2 patients with abnormal REM-sleep-associated hypersomnia, 7 patients with idiopathic hypersomnia, 2 patients...
Cataplexy in the narcoleptic canine may be modulated by systemic administration of monoaminergic compounds. In the present study, we have investigated the effects of monoaminergic drugs on cataplexy in narcoleptic canines when perfused locally via microdialysis probes in the amygdala, globus pallidus/putamen, basal forebrain, pontine reticular formation and ventral tegmental area of narcoleptic...
Vigilance decline in narcolepsy has been observed repeatedly in task performance . However, the nature of this vigilance effect is not exactly clear. In order to investigate vigilance problems in narcolepsy, it would be informative to examine to what extent narcolepsy patients differ from healthy people in naturally occurring vigilance fluctuations throughout the day. A general tendency to perf...
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