The age distribution of esterases in the interstitial cell of the mouse testis was studied between birth and the end of the tenth week of postnatal life by using the substrates O-acetyl-s-bromoindoxyl, a-naphthyl acetate, naphthol AS acetate, naphthol AS-LC acetate, and naphthol AS-D acetate. With indoxyl acetate, esterase activity is prominent at birth and wanes over the first 2 weeks of postn...

The glucuronic acid adducts of 1-naphthol, 2-naphthol and 4-methylumbelliferone activate microsomal UDP-glucuronyltransferase (EC 2.4.1.17) when the enzyme is assayed with p-nitrophenol as aglycone. Phenyl glucuronide and oestriol 3beta-glucuronide also activate UDP-glucuronyltransferase. but to a lesser extent. Activation by glucuronides is not dependent on metal ions, but is blocked by prior ...

Abstract Background Quinolones and cephalosporins are antibiotic agents with activity against Gram-positive Gram-negative bacteria. They contain chromophores amine groups which electron-rich centres capable of donating electrons to electron-deficient compounds. A survey the literature revealed that 2, 4-dinitro-1-naphthol, a nitroaromatic useful in chemical synthesis, can accept charge transfer...

A facile and eminent method has been reported for the preparation of amido alkyl naphthols. Amido naphthol derivatives were synthesized by condensation pyrazole aldehydes, β-naphthol acetamide in presence a heterogeneous SiO2 supported sodium hydrogen sulphate catalyst using acetic acid as solvent. This protocol is advantageous its shorter reaction hours, simplest workup technique, excellent yi...

The tetrabutylammonium chloride complex with rac-1,1′-bi-2-naphthol crystallizes in monoclinic space group P21/n, unit-cell parameters of; a = 10.4941(1)Å, b 26.3302(3)Å, c 11.5290(1)Å, α 90°, β 100.0154(5)°, γ 90 °, V 3137.05(5)Å3, and Z 4. packing mode, hydrogen bonding network, crystal data suggest that the structure is isomorphous reported of bromide rac-1,1′-bi-2-naphthol.2

The insecticide carbaryl and its metabolite 1-naphthol cause partial uncoupling of karyokinesis and cytokinesis in V79 Chinese hamster fibroblasts; karyokinesis is blocked in metaphase, the microtubules of the spindle depolymerize and the chromosomes and spindle remnants become displaced to the periphery of the cell. A high frequency of these disturbed cells elongate and a smaller fraction init...

tow new compound of type [(chelate)2cu-oh-cu(chelate)2] x3.nh2o, where chelate=1,10-phenanthroline; x=cl¯(n=3.5) and chelate=4,4'-dimethyl-2,2'-bipyridine;  (n=5) have been synthesized and their properties investigated. the complexes show room temperature magnetic moment order of 1.0 b.m. per copper atom. the x-band esr spectrum of powdered samples at room temperature shows typical dm=1 transit...

Cunninghamella elegans grown on Sabouraud dextrose broth in the presence of naphthalene produced six metabolites. Each product was isolated and identified by conventional chemical techniques. The major metabolites were 1-naphthol (67.9%) and 4-hydroxy-1-tetralone (16.7%). Minor products isolated were 1,4-naphthoquinone (2.8%), 1,2-naphthoquinone (0.2%), 2-naphthol (6.3%), and trans-1,2-dihydrox...

Levels of glutathione (GSH) in tumour tissue may be important in determining the clinical response to certain anticancer agents. Recent reports have suggested that D,L-buthionine-S,R-sulphoximine (BSO), a specific inhibitor of GSH synthesis, may be used to deplete tumour cell GSH and thus increase the therapeutic ratio of these agents. We have previously shown that 1-naphthol is a potential ant...

Conventional methods to determine esterase activity from insects are composed of a three-step process where the enzyme is allowed to hydrolyze a 1-naphthyl acetate substrate, that reaction is quenched by a SDS detergent, and then a Fast Blue B dye complex is formed with 1-naphthol, the product of 1-naphthyl acetate hydrolysis. These methods measure dye-product complex rather than the product, 1...