AIM The aim of this work was to develop pH-responsive nanoparticles encapsulating CdtB and to demonstrate that these particles represent a potential therapeutic agent for gastric cancer. MATERIALS & METHODS Chitosan/heparin nanoparticle-encapsulated CdtB was prepared and the delivery efficiency was monitored by confocal laser scanning microscopy. The molecular basis of the nanoparticle-encaps...

we have performed a density functional theory investigation on the structural and electronic properties of pristine and nitrogen-doped tio2 anatase nanoparticles as the adsorbents for removal and degradation of hydrazine molecules in the environment. we have presented the most stable adsorption configurations and examined the interaction of hydrazine molecule with these doped and undoped nanopa...

The mechanical behavior of TiO2 nanoparticle-reinforced resin-based dental composites was characterized in this work using a three-dimensional nanoscale representative volume element. The impacts of nanoparticle volume fraction, aspect ratio, stiffness, and interphase zone between the resin matrix and nanoparticle on the bulk properties of the composite were characterized. Results clearly demon...

The increasing use of nanomaterials raises concerns about the long-term effects of chronic nanoparticle exposure on human health. However, nanoparticle exposure is difficult to evaluate non-invasively using current measurement techniques. Here we show that the skin is an important site of nanoparticle accumulation following systemic administration. Mice injected with high doses of gold nanopart...

An eco-friendly green mediated synthesis of inorganic nanoparticle is a fast growing research in the limb of nanotechnology. This study reports the synthesis of silver Nanoparticle by using commercially available spice Elettaria cardamomom without the use of toxic chemicals. Visually, the formation of silver Nanoparticle was confirmed by observing the colour changes from pale yellow to dark bro...

The convergence of biofabrication with nanotechnology is largely unexplored but enables geometrical control of cell-biomaterial arrangement combined with controlled drug delivery and release. As a step towards integration of these two fields of research, this study demonstrates that modulation of electrostatic nanoparticle-polymer and nanoparticle-nanoparticle interactions can be used for tunin...

This paper proposes a high precision method for nanoparticle counting and sizing using a microring resonator-waveguide system that contains a flow-through nanopore. Theoretical analysis is carried out based on the coupled-mode theory, showing that when the nanoparticle passes the nanopore a temporal pulse signal can be detected and that the peak amplitude depends linearly on the nanoparticle vo...

We have achieved highly localized control of pattern formation in two-dimensional nanoparticle assemblies by direct modification of solvent dewetting dynamics. A striking dependence of nanoparticle organization on the size of atomic force microscope-generated surface heterogeneities is observed and reproduced in numerical simulations. Nanoscale features induce a rupture of the solvent-nanoparti...

Arrays of metal nanoparticles in an organic matrix have attracted a lot of interest due to their diverse electronic and optoelectronic properties. Recent work demonstrates that nanoparticle arrays can be utilized as a template structure to incorporate single molecules. In this arrangement, the nanoparticles act as electronic contacts to the molecules. By varying parameters such as the nanoparti...

The interactions between nanosized particles and living systems are commonly mediated by what adsorbs to the nanoparticle in the biological environment, its biomolecular corona, rather than the pristine surface. Here, we characterize the adhesion toward the cell membrane of nanoparticles of different material and size and study how this is modulated by the presence or absence of a corona on the...