Mycobacteriosis is a chronic disease of freshwater and marine fish. In the present study, Mycobacterium fortuitum from a diseased gold fish, Carassius auratus was isolated and identified by biochemical and molecular (PCR) method. The isolate was found to be resistant to rifampicin, isoniazid, pyrazinamide and ethambutol and myoconda® a nanodrug combination of rifampicin, clarithromycin and clof...

Multi-Modal Targeting Strategy for Breast Cancer In article number 2000145 by Sreejith Raveendran, D. Sakthi Kumar and co-workers, a multi-modal targeting strategy breast cancer using combinatorial nanodrug complex is studied ultra-structural visualization of subcellular multiple parallel damage caused to cells are demonstrated serial-block-face scanning electron microscopy. Mechanistic conform...

Infectious lung diseases are inflammatory of the lungs caused by infectious agents such as bacteria, viruses or fungi. Oral intravenous administration antibiotics is most common method treatment, but some drugs have poor release stability, high systemic toxicity and susceptibility to drug resistance. Nanodrug delivery systems promising alternatives for treatment diseases, because they provide a...

aim and background: hepatocellular carcinoma (hcc) -an aggressive malignancy with high rate of mortality- is the third cause of cancer related death, worldwide. cisplatin is a chemotherapy drug used for treatment of hcc. however, serious side effects of drug limit the therapeutic administer dose.  nanotechnology based devices such as liposome nanoparticles are capable to overcome these drawback...

Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infections, with an oral bioavailability of only 10-20% [limiting absorption in gastrointestinal tract to duodenum and jejunum] and half-life of about 3 h, and is soluble only at acidic pH (pKa 2.27). Mucoadhesive polymeric nanodrug delivery systems of acyclovir have been designed and optimized using 2(3) full factori...

Different mechanisms in cancer cells become resistant to one or more chemotherapeutics is known as multidrug resistance (MDR) which hinders chemotherapy efficacy. Potential factors for MDR includes enhanced drug detoxification, decreased drug uptake, increased intracellular nucleophiles levels, enhanced repair of drug induced DNA damage, overexpression of drug transporter such as P-glycoprotein...