نتایج جستجو برای: nanoconjugate

تعداد نتایج: 106  

2014
Alicia Fernandez-Fernandez Romila Manchanda Denny A Carvajal Tingjun Lei Supriya Srinivasan Anthony J McGoron

Near-infrared dyes can be used as theranostic agents in cancer management, based on their optical imaging and localized hyperthermia capabilities. However, their clinical translatability is limited by issues such as photobleaching, short circulation times, and nonspecific biodistribution. Nanoconjugate formulations of cyanine dyes, such as IR820, may be able to overcome some of these limitation...

Journal: :Journal of inorganic biochemistry 2014
Carl M Blumenfeld Bryce F Sadtler G Esteban Fernandez Lily Dara Cathie Nguyen Felix Alonso-Valenteen Lali Medina-Kauwe Rex A Moats Nathan S Lewis Robert H Grubbs Harry B Gray Karn Sorasaenee

We are investigating the biological and biomedical imaging roles and impacts of fluorescent metallocorrole-TiO2 nanoconjugates as potential near-infrared optical contrast agents in vitro in cancer and normal cell lines. The TiO2 nanoconjugate labeled with the small molecule 2,17-bis(chlorosulfonyl)-5,10,15-tris(pentafluorophenyl)corrolato aluminum(III) (1-Al-TiO2) was prepared. The nanoparticle...

Journal: :Molecules 2017
Roxana Cristina Popescu Ecaterina Andronescu Bogdan Ștefan Vasile Roxana Truşcă Adina Boldeiu Laurențiu Mogoantă George Dan Mogoșanu Mihaela Temelie Mihai Radu Alexandru Mihai Grumezescu Diana Savu

Nanotechnology has been successfully used for the fabrication of targeted anti-cancer drug carriers. This study aimed to obtain Fe₃O₄ nanoparticles functionalized with Gemcitabine to improve the cytotoxic effects of the chemotherapeutic substance on cancer cells. The (un) functionalized magnetite nanoparticles were synthesized using a modified co-precipitation method. The nanoconjugate characte...

2011
Jameel Ahmad Khan Rachel A. Kudgus Annamaria Szabolcs Shamit Dutta Enfeng Wang Sheng Cao Geoffry L. Curran Vijay Shah Steven Curley Debabrata Mukhopadhyay J. David Robertson Resham Bhattacharya Priyabrata Mukherjee

BACKGROUND Pancreatic cancer is the fourth leading cause of cancer related deaths in America. Monoclonal antibodies are a viable treatment option for inhibiting cancer growth. Tumor specific drug delivery could be achieved utilizing these monoclonal antibodies as targeting agents. This type of designer therapeutic is evolving and with the use of gold nanoparticles it is a promising approach to ...

2014
Sivakumar Balasubramanian Aswathy Ravindran Girija Yutaka Nagaoka Seiki Iwai Masashi Suzuki Venugopal Kizhikkilot Yasuhiko Yoshida Toru Maekawa Sakthikumar Dasappan Nair

The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon...

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