Monodisperse Pt nanoparticles supported on a graphitized carbon black (GC; 150 m(2) g(-1)), which exhibits higher resistance to carbon corrosion than a conventional high-surface-area carbon black (CB; 800 m(2) g(-1)), were prepared by the nanocapsule method. Three kinds of 50 wt%-Pt loaded catalysts (our nanocapsule Pt/GC, a commercial Pt/GC, and a commercial Pt/CB) were subjected to the durabi...

Suspensões de nanocápsulas contendo melatonina foram preparadas pelo método de deposição interfacial e caracterizadas (tamanho, morfologia e eficiência de encapsulação). Foram avaliadas as influências do tipo de polímero, de óleo e de tensoativo sobre as características dos produtos. A eficiência de encapsulação da melatonina variou de 30% a 56% e a natureza do polímero foi o parâmetro de maior...

The aim of the present work is to develop a method for the patterning of the nanocapsule arrays immobilized on solid surfaces applying electron beam treatment to the formed layers of nanoparticles with magnetic materials in the cavity or in the shell. The successful patterning was demonstrated by optical microscopy, while morphology and structure of the formed system were analyzed by atomic for...

Doxorubicin (Dox) clinical use is limited by dose-related cardiomyopathy, becoming more prevalent with increasing cumulative doses. Previously, we developed Dox-loaded lipid-core nanocapsules (Dox-LNC) and, in this study, we hypothesized that self-assembling and interfacial reactions could be used to obtain arginylglycylaspartic acid (RGD)-surface-functionalized-Dox-LNC, which could target tumo...

Protected and specific delivery of nucleic acids to malignant cells remains a highly desirable approach for cancer therapy. Here we present data on the physical and chemical characteristics, mechanism of action, and pilot therapeutic efficacy of a tenfibgen (TBG)-shell nanocapsule technology for tumor-directed delivery of single stranded DNA/RNA chimeric oligomers targeting CK2αα' to xenograft ...

The local environment within a recently developed anthracene-shelled micelle (ASM), which is a micelle-like nanocapsule composed of anthracene-embedded amphiphiles, was investigated by steady-state and time-resolved spectroscopy of an encapsulated solvatochromic fluorescent probe molecule, coumarin 153 (C153). The absorption maximum of encapsulated C153 (452 nm) is more red-shifted than that of...

method for the analysis of 1,3-dihydroxy-2-methylxanthone (DHMXAN) in biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanosphere and nanocapsule formulations is developed and validated. The method does not require any complex sample extraction procedure. Chromatographic separation is made with a reversed-phase C18 column, using methanol–water (90:10, v/v) containing 1% (v/v) acetic acid as ...