Self-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes of Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. All commercially available nano-formulations of chemotherapeutics currently consist of SAS. According to our knowledge, a specific toxicity comparison based on material differences has not ye...

Nimodipine (NM), as a lipophilic calcium channel blocker indicated for the prevention and treatment of neurological disorders, suffers from an extensive first pass metabolism, resulting in low oral bioavailability. Polymeric micelles, self-assembled from amphiphilic polymers, have a core-shell structure which makes them unique nano-carriers with excellent performance as drug delivery. This inve...

Structural transitions involving shape changes play an important role in cellular physiology. Such transition can be conveniently induced in charged micelles by increasing ionic strength of the medium. Shape changes have recently been shown to result in altered packing and lowering of micellar polarity. As a consequence of reduced polarity, the ionization states of micelle-bound molecules vary ...

We use a stochastic molecular dynamics simulation method to investigate the effect of optimal head group area in amphiphilic self-assembly. For a fixed tail geometry, we choose several sizes of the effective head group area and carry out a detailed study of how this affects the critical micelle concentration ~CMC!, the cluster distribution, and the shape of micelles for different concentrations...

As nano-scale drug delivery systems, smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are attractive. In this work, a biocompatible and pH-sensitive copolymer is synthesized through bridging poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) block and poly (D, L-lactide) (...

Nano micelles of sodium dodecyl sulphate in water were prepared as local lipophilic media for the organisation of interacting chromophores. Such arrangements were controlled by peripheric substituents to operate either as isolated chromophores or as skew oriented pairs where H-type transitions cause hysochromic absorption and J-type transitions bathochromic fluorescence. As a consequence, large...

In this work, micelles composed of doxorubicin-conjugated Y-shaped copolymers (YMs) linked via an acid-labile linker were constructed. Y-shaped copolymers of mPEG-b-poly(glutamate-hydrazone-doxorubicin)2 and linear copolymers of mPEG-b-poly(glutamate-hydrazone-doxorubicin) were synthesized and characterized. Particle size, size distribution, morphology, drug loading content (DLC) and drug relea...

A versatile and facile route to control the composition of plasmonic nanoparticles (NP) aligned in a configuration of two dimensional nano-arrays is presented by applying galvanic displacement reactions on a pre-defined noble metal NP arrays which were prepared from diblock copolymer inverse micelles containing metal precursors.

Life secrets lie in invisible world which excites imagine to study. Nowadays, nanotechnology became public terminology for applications of nano-size (nm = 10 meter) in all sciences. Nano-particles already present in nature such as living cell structures (proteins, DNA, polysaccharides, membranes, etc.) and natural structures such as casein micelles or starch, the folding of globular proteins an...