Resistance to aspirin and its cytotoxicity significantly limits its therapeutic applications. Nano-liposomal encapsulation of aspirin can reduce its cytotoxicity. In this study, aspirin encapsulated nano-liposomes (AS-NL) was prepared and its performance in drug delivery and cytotoxicity was evaluated. The effects of two independent variables including: number of freeze/thawing cycles and conce...

In addition to increasing the efficacy of various drugs, Nanoparticles reduce their side effects. In this study, different nanoparticle formulations of Doxorubicin anticancer drugs were prepared. The efficacy of the formulations produced in the cell culture medium was studied compared with the free drug. Reverse phase evaporation was used to form the liposome containing do...

Liposomal drug carriers are nano-scale, spherical particles with a phospholipid bilayer surrounding an aqueous core and are commonly used for chemotherapeutic delivery. Chemotherapy efficacy is limited by toxicity and tumor drug resistance; however, with increased circulation and improved tumor deposition due to the enhanced permeability and retention effect, liposomes increase treatment effica...

Liposomes have a variety of applications as model systems to study enclosed biological membranes, as delivery vehicles for a variety of drugs and as micro- and nano-reactors, amongst others. However, preparation of liposomes requires use of expensive raw material (synthetic lipids) from specialized commercial suppliers, and ability to make reproducible preparations remains a specialized art til...

Integration of liposomes in polymer matrix is a new concept of controlled drug delivery system. Those kind of materials allow to control dosage of applied drug and time of its release. Certain types of liposomes are unstable, so they require structural support. The main aim of the paper is to investigate how polymers influence aggregation of liposomes. Two different polymers were used for this ...

Niosomes are considered as novel nano-carrier in the drug delivery systems. These much more stable than other nano-carriers like liposomes and nanoparticles. It is an example for targeted control release of medication. The entrapped into lipid core so that it prevents from leaching. Here will be only to desired cell/tissue not non-targeted cells. By giving this formulation we can thereby reduce...

PURPOSE Imatinib inhibits platelet-derived growth factor receptor (PDGFR), and evidence shows that PDGFR participates in the development and progression of cervical cancer. Although imatinib has exhibited preclinical activity against cervical cancer, only minimal clinical therapeutic efficacy was observed. This poor therapeutic efficacy may be due to insufficient drug delivery to the tumor cell...

Water-soluble disulfonato-subphthalocyanines (SubPcs) or hydrophobic nano-encapsulated SubPcs are efficient probes for the fluorescence imaging of cells. 20 nm large liposomes (TEM and DLS) incorporated about 13% SubPc. Moreover, some of these fluorophores were found to be pH activatable.

The encapsulation of enzymes in microenvironments and especially in liposomes, has proven to greatly improve enzyme stabilization against unfolding, denaturation and dilution effects. Combining this stabilization effect, with the fact that liposomes are optically translucent, we have designed nano-sized spherical biosensors. In this work liposome-based biosensors are prepared by encapsulating t...

Purpose: To evaluate lymphatic system targeting and inhibitory ability of N15P nano-liposomal preparation (naLipo-N15P) of CXCR4 receptor antagonist in HIV infection. Methods: Chemotactic and chemotaxic inhibition activity assays were used to analyze the biological activity of naLipo-N15P. The anti-HIV potential of NaLipo-N15P in vitro was evaluated when NaLipoN15P combined with the peripheral ...