Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medication...

Background: Regarding the negative effects of androgenic anabolic steroids (AASs) abuse, the long-term effect of nandrolone decanoate with/without two intensities of endurance exercise training was investigated on heart tissue and electrocardiogram (ECG) in rats. Methods: The experiment was conducted on 63 male Wistar rats, which were 4 months old. The rats were divide into groups of control (C...

Field studies of androgen pharmacology are complicated by the necessity to collect, process, and store blood samples in a central facility. We have assessed the feasibility of using capillary blood spots collected by fingerprick and dried on filter paper for pharmacokinetics and pharmacodynamic measurements with nandrolone and testosterone RIAs modified for extracts from capillary blood spots. ...

Objective: The aim of the present study was to determine whether anabolic androgenic steroids (AAS) have an effect on the levels of calcitonin gene-related peptide (CGRP) in the rat brain, using nandrolone decanoate as a prototype steroid. Method: Male Sprague-Dawley rats received daily intramuscular injections of nandrolone decanoate (15 mg/kg) for 14 days. The effect of AAS on CGRP immunoreac...

Functionally overloading rat soleus muscle by synergist ablation induces a rapid increase in mass. Muscle remodeling during the first week of overload is critical for the overload-induced growth. Anabolic steroid modulation of this overload-induced remodeling response is not well understood. The purpose of this study was to determine whether pretreatment with nandrolone decanoate, a clinically ...

Background: Androgenic, Wnt and Notch pathways regulate progenitor development through unknown mechanisms. Results: Upregulation of Numb was blocked by Wnt inhibitors and required -catenin. Nandrolone promoted binding of ß-catenin to the Numb promoter and thereby increased its activity through Tcf bound at two consensussites. Conclusion: Wnt/-catenin signaling mediates nandrolone-induced Numb...

Anabolic androgenic steroids and central monoaminergic systems Supratherapeutic doses of nandrolone decanoate affect dopamine and serotonin

Introduction: The effect of regular exercise in decreasing the incidence of heart diseases is well known. The abuse of anabolic androgenic steroids (AAS) has been associated with cardiovascular disorders. Uncoupling proteins (UCPs) transport protons across the inner mitochondrial membrane thereby proton gradient can be diminished by the action of UCPs. This process will result in the uncoupl...

The aim of the present study was to investigate the effects of anabolic-androgenic steroids and resistance training (RT) on insulin sensitivity in ovariectomized rats. Adult female Wistar rats were divided into ten experimental groups (n = 5 animals per group): (1) sedentary (Sed-Intact); (2) sedentary ovariectomized (Sed-Ovx); (3) sedentary nandrolone (Sed-Intact-ND); (4) sedentary ovariectomi...