OBJECTIVES We performed a study to assess the efficacy of fenoldopam mesylate (a specific agonist of the dopamine-1 receptor) as compared with N-acetylcysteine (NAC) in preventing contrast agent-associated nephrotoxicity (CAN). BACKGROUND Prophylactic administration of NAC, along with hydration, prevents CAN in patients with chronic renal insufficiency who are undergoing contrast media admini...

A quantitative reversed-phase HPLC method has been developed that enables determination of both low endogenous and high therapeutic concentrations of N-acetylcysteine (NAC) in plasma. The compound is detected fluorimetrically after derivatisation with ortho-phthalaldehyde in the presence of a primary amine. Validation of the method revealed injection and method repeatability were good. The line...

Introduction Pathologic grooming disorders can lead to clinically significant distress and functional impairment. Various psychopharmacological nonpharmacological treatments have been used ameliorate the symptoms of these disorders. N-Acetylcysteine (NAC) is a newer modality in treatment has shown promise obsessive-compulsive related Objectives To determine whether NAC useful body-focused repet...

BACKGROUND Pre-existing chronic renal failure is a significant risk factor for acute renal failure (ARF) after cardiac surgery. N-acetylcysteine (NAC) has been shown to prevent contrast media-induced ARF. Our objective was to evaluate whether i.v. NAC has renoprotective effects in patients with mild renal failure undergoing cardiac surgery. METHODS In this prospective, randomized, double-blin...

OBJECTIVES We investigated whether N-acetylcysteine (NAC), a reduced thiol that modulates redox state and forms adducts of nitric oxide (NO), improves endothelium-dependent vasomotion. BACKGROUND Coronary atherosclerosis is associated with endothelial dysfunction and reduced NO activity. METHODS In 16 patients undergoing cardiac catheterization, seven with and nine without atherosclerosis, ...

N-acetylcysteine (NAC), an analogue and precursor of reduced glutathione, has been in clinical use for more than 30 yrs as a mucolytic drug. It has also been proposed for and/or used in the therapy and/or prevention of several respiratory diseases and of diseases involving an oxidative stress, in general. The objective of the present study was to evaluate the effect of long-term treatment with ...

airway mucus hypersecretion and increased oxidative stress are clinical and pathophysiological features of asthma exacerbation. we studied effects of n-acetylcysteine (nac) as a mucolytic and antioxidant agent in asthma exacerbation. in this randomized, single-blinded, placebo-controlled study 50 patients ( 17 male, 33 female, mean age 48.94±13.68) with asthma exacerbation were randomized to re...

NO transfer reactions between protein and peptide cysteines have been proposed to represent regulated signaling processes. We used the pharmaceutical antioxidant N-acetylcysteine (NAC) as a bait reactant to measure NO transfer reactions in blood and to study the vascular effects of these reactions in vivo. NAC was converted to S-nitroso-N-acetylcysteine (SNOAC), decreasing erythrocytic S-nitros...