Novel 3-C-alkylated-Neu5Ac2en derivatives have been designed to target the expanded active site cavity of influenza virus sialidases with an open 150-loop, currently seen in X-ray crystal structures of influenza A virus group-1 (N1, N4, N5, N8), but not group-2 (N2, N9), sialidases. The compounds show selectivity for inhibition of H5N1 and pdm09 H1N1 sialidases over an N2 sialidase, providing e...

The HF/3s2pld and MP213s2pld structures, energies and vibrational frequencies were calculated for ten N8 isomers, corresponding to ten analogous CH structures. Comparative calculations using density functional theory (DFT), with a cc-pVTZ basis set, were also performed. All ten structures were found to be local minima on the energy hypersurface at the Hartree-Fock (HF) level, whereas at the sec...

The increased industrialization and overuse of natural resources for energy, such as fossil fuels, have led to the energy crises environmental issues that plague world in twenty-first century. production biodiesel from algae has recently gained attention a potentially useful alternative fuel is both environmentally friendly easy obtain. In this work, effects various pH levels on biomass oil Chl...

We have studied the urinary excretion of free and acetylated polyamines in hepatoma-bearing Buffalo rats during the period of linear growth of the tumor mass. The excretion of nonconjugated polyamines was unchanged. N1-Acetylspermidine excretion did not parallel the linear increase in tumor mass but increased exponentially. Enhancement of N8-acetylspermidine excretion above control levels was o...

We study the relationship between the sizes of two-way finite automata accepting a language and its complement. In the deterministic case, for a given automaton (2dfa) with n states, we build an automaton accepting the complement with at most 4n states, independently of the size of the input alphabet. Actually, we show a stronger result, by presenting an equivalent 4n-state 2dfa that always hal...

Reaction of N3,N8-diacyl 6-thia-3,8-diazabicyclo/3.2. l./octan-2-one (I) with PC15 or S02Cl2 gave 6-chloro substituted N2,N5-diacyl 7-thia-2,5-diazabicyclo/2.2.2./octan-3-one (II). Treatment of II with water yielded the 6-hydroxy derivative (III) while reaction with methanol gave the 6-methoxy derivative (IV). Under the same reaction conditions the mono N8-acyl derivative (V) gave a mixture of ...

The current–voltage characteristics I(V) of model organic devices are studied under ultra-high-vacuum conditions. Active materials are N,N8-bis-(1-naphthyl)-N,N8-diphenyl1-1,1-biphenyl1-4,48-diamine ~a-NPD! and pentacene, electrode materials are polycrystalline Au and the conductive polymer poly~3,4-ethylenedioxythiophene!/poly~styrenesulfonate! ~PEDOT/ PSS!. Despite a similar work function of ...

Role of asparagine-linked (N-linked) oligosaccharide side chains in the maturation and the function of influenza virus neuraminidase (NA) subtype N8 was examined by site-directed mutagenesis and vaccinia virus expression system. Mutations in the consensus sequence for N-linked glycosylation at Asn 84 or 398 prevent the proper maturation of mutant NAs. On the contrary, mutation at Asn 144, that ...

In the present study, 78 lactic acid bacteria (LAB) strains were screened for the antagonistic activity against Campylobacter jejuni and 15 LAB strains with high bactericidal capacity were selected for further study through the analysis of the inhibition zone of LAB spent culture supernatant on the growth of C. jejuni. Among these strains, four isolates, Lactobacillus plantarum N8, N9, ZL5 and ...