Treatment of Chinese hamster ovary cells with alpha-difluoromethylornithine for 3 days, followed by exposure to cycloheximide, led to an unregulated, rapid and massive accumulation of polyamine analogues. This accumulation led to cell death by apoptosis within a few hours. Clear evidence of DNA fragmentation was seen in response to both N-terminally ethylated polyamines and to polyamines contai...

N1-ethyl-N11-[(cyclopropyl)methyl]-4,8,-diazaundecane (CPENSpm) is a polyamine analogue that represents a new class of antitumor agents that demonstrate phenotype-specific cytotoxic activity. However, the precise mechanism of its selective cytotoxic activity is not known. CPENSpm treatment results in the superinduction of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase (...

Activation of the feeding motor program (FMP) increases the force of ventricular contractions in heart/central nervous system (CNS) preparations of the terrestrial slug Limax maximus (Linnaeus). The FMP-induced increase in ventricular activity requires innervation of the heart by abdominal ganglion nerves N9 and N11. Application of the small cardioactive peptides SCPA and SCPB to isolated prepa...

Let f be a nonconstant meromorphic function defined in the whole complex plane . It is assumed that the reader is familiar with the notations of the Nevanlinna theory such as T r, f , m r, f ,N r, f , and S r, f , that can be found, for instance, in 1–3 . Let f and g be two nonconstant meromorphic functions. Let a be a finite complex number. We say that f and g share the value a CM counting mul...

We introduce our VLT-FLAMES survey of massive stars in the Galaxy and the Magellanic Clouds, giving details of the observations in our younger fields in the LMC and SMC. In particular we highlight a new O2.5type star discovered in N11, and Be-type stars in NGC 346 with permitted Fe II emission lines in their spectra. We give an overview of the distribution of spectral types in these fields and ...

The iron content in seminal plasma of normal (n19), oligozoospermic (n11), azoospermic (n12), oligoasthenozoospermic (n19), and asthenozoospermic (n17) subjects was estimated by using atomic absorption spectrophotometer. The concentration of iron in normal seminal plasma varied from 265 to 365 mg%. The source of iron in seminal plasma seems to be the adnexal glands and not spermatozoa, as azoos...

We show how to compute for n-vertex planar graphs in O(n11/6 polylog(n)) expected time the diameter and the sum of the pairwise distances. The algorithms work for directed graphs with real weights and no negative cycles. In O(n15/8 polylog(n)) expected time we can also compute the number of pairs of vertices at distance smaller than a given threshold. These are the first algorithms for these pr...

This study analyses the physical stature of runaway apprentices and military deserters based on advertisements collected from 18-century newspapers, in order to explore the biological welfare of colonial and early-national Americans. The results indicate that heights declined somewhat at mid-century, but increased substantially thereafter. The findings are generally in keeping with trends in mo...