نتایج جستجو برای: n 43
تعداد نتایج: 1053784 فیلتر نتایج به سال:
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are types of major TDP-43 (43-kDa TAR DNA-binding protein) proteinopathy. Cortical TDP-43 pathology has been analyzed in detail in cases of FTLD-TDP, but is still unclear in cases of ALS. We attempted to clarify the cortical and subcortical TDP-43 pathology in Japanese cases of sporadic ALS (n = 96) using an antibo...
GAP-43 (neuromodulin) is a protein kinase C substrate that is abundant in developing and regenerating neurons. Thioester-linked palmitoylation at two cysteines near the GAP-43 N terminus has been implicated in directing membrane binding. Here, we use mass spectrometry to examine the stoichiometry of palmitoylation and the molecular identity of the fatty acid(s) attached to GAP-43 in vivo. GAP-4...
TDP‐43 proteinopathy is a kind of neurodegenerative diseases related to the TAR DNA‐binding protein 43‐kDa molecular weight (TDP‐43). The typical include amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), Parkinson's (PD) and so on. As process cannot be blocked or slowed down, these patients have poor quality life prognosis, bring huge burde...
Universal traversal sequences for cycles require length (n 1:43), improving the previous bound of (n 1:33). For d 3, universal traversal sequences for d-regular graphs require length (d 0:57 n 2:43). For constant d, the best previous bound was (n 2:33).
A cell variant (VR-43) resistant to the cytotoxic effect of N-methyl-N'-nitro-N-nitrosoguanidine and N-methyl-N'-nitro-N-nitrosourea was isolated from Chinese hamster V79 cells for use in studies of the relationship among cell survival, mutagenesis, and DNA repair by alkylating agents. Resistance to ouabain or 6-thioguanine was used as the genetic marker. After treatment with N-methyl-N'-nitro-...
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