We compared the significance of several serum markers to evaluate the activity of Pneumocystis carinii pneumonia (PCP) in an immunocompromised patient. We successively measured KL-6, an amino-terminal propeptide of Type III procollagen (PIIINP), and the cytokeratin 19 fragment (CK19) in the sera of a patient with PCP. Interestingly, PIIINP, KL-6, and CK19 levels in the sera did not increase at ...

In 1997, the United States’ federal guidelines on racial classification were amended to permitindividual respondents to identify themselves as members of more than one race. This measure,taken at the urging of a vocal community of mixed-race individuals and organizations, was seenby many as having important consequences. In this article I examine the predictions about theimpact ...

Interleukin-21 (IL-21) can be produced by CD8 T cells from HIV-1-infected individuals and those with autoimmune disease, but the mechanism remains poorly understood. Here we demonstrate that IL-21-producing CD8 T cells are not associated with CD4 depletion and are absent in patients with idiopathic CD4 lymphocytopenia. Instead, IL-21 production by CD8 T cells was associated with high levels of ...