5-phenyl-1,3,4-thiadiazol-2-amine (1), on reaction with substituted indolaldehyde in presence of glacial acetic acid give N-((2-substituted indol-3-yl)methylene)-5-phenyl-1,3,4-thiadiazol-2-amine (26). The compounds 2-6 when treated with acetyl chloride in presence of triethylamine undergo cycloaddition to produce 4-(2-substituted indol-3-yl)-1-(5-phenyl-1,3,4-thiadiazol-2-yl)azetidin-2-one (7-...

A new series of 2-(5-(2-chloroquinolin-3-yl)-3-(aryl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)ones 4a-l have been prepared and characterized by IR, NMR and mass spectroscopy. The synthesized compounds have been screened for antimicrobial activity against microbial strains: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes, Candida albicans, Aspergillus nig...

Optimized reaction conditions are developed to obtain a series of [(7-chloroquinolin-4-yl)sulfanyl] alcohol derivatives as intermediates prepare range (7-chloroquinolin-4-ylthio) alkylbenzoate derivatives. The structures all the synthesized compounds confirmed from their infrared and nuclear magnetic resonance spectral data, by elemental analysis. In silico ADME/Tox profiling studies molecules ...

The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

BACKGROUND Thiazolidine-2, 4-diones (TZDs) have become a pharmacologically important class of heterocyclic compounds since their introduction in the form of glitazones into the clinical use for the treatment of type 2 diabetes. TZDs lower the plasma glucose levels by acting as ligands for gamma peroxisome proliferators-activated receptors. In addition, this class of heterocyclic compounds posse...