OBJECTIVE The aim of this study was to investigate the most robust predictor of myocardial viability among stress/rest reversibility (coronary flow reserve [CFR] impairment), (201)Tl perfusion status at rest, (201)Tl 24 hours redistribution and systolic wall thickening of (99m)Tc-methoxyisobutylisonitrile using a dual isotope gated myocardial perfusion single-photon emission computed tomography...

Myocardial perfusion SPECT is one of the most common imaging techniques performed in nuclear medicine departments. To avoid misleading interpretation, it is necessary to address the quality control and technical problems. The truncation artifact occurs when the patient size is large relative to the field of view of the camera, causing false perfusion defects in the LV myocardium, misinterpreted...

Background: Real cardiac phantoms are often used to assess the performance of software for gated single-photon emission computed tomography(SPECT). However, these phantoms have disadvantages in that they are not very similar to actual hearts and setting a perfusion defect is not easy. To overcome these problems, we developed a digital myocardial phantom, named%Myo-Simu'. The aims of this study ...

UNLABELLED The impact of arrhythmias on the evaluation of perfusion data from myocardial gated SPECT has been assessed by comparing arrhythmic patients with nonarrhythmic patients or by simulating rhythm disturbances. Whether gating-related artifacts may have a clinically relevant influence on the evaluation of perfusion in atrial fibrillation (AF) patients is still uncertain. Recently, collect...

Introduction: Myocardial perfusion imaging (MPI) is an important imaging modality in managing patients with cardiovascular disease. MPI has a significant role in diagnosis and management of cardiovascular disease; however it is subjected to different artifacts. Combining pharmacologic stress with submaximal exercise reduces side effects, improves image quality, and enhances the...

UNLABELLED The aim of this study was to determine the effect of perfusion defect and imaging sequence on the evaluation of myocardial stunning with gated perfusion SPECT. METHODS A dynamic mathematic cardiac torso phantom was used to create 100 gated SPECT simulations (50 stress-rest and 50 rest-stress sequences) with a wide range of perfusion defects. No segmental wall motion abnormalities w...

Since the development of gated SPECT imaging approximately 10 y ago, this technique is now almost universally used as an adjunct for radionuclide perfusion imaging, enabling the assessment of perfusion along with determination of regional and global left ventricular function in the same examination. The gated SPECT determination of the left ventricular ejection fraction and volumes has been ext...

Introduction: The aim of this study was to evaluate the effect of successful kidney transplantation (KT) on myocardial perfusion and left ventricular function by both qualitative (visual) interpretation and semiquantitative parameters, using myocardial perfusion scintigraphy with gated-single photon emission computed tomography (gated-SPECT) in patients suffering from end-stage renal disease. M...

OBJECTIVE To investigate the effect of cardiomyocyte proliferation induced by human hepatocyte growth factor (HGF) in pigs with chronic myocardial infarction (CMI). METHODS A steerable, deflectable 7F catheter incorporating a 27-guage needle was advanced percutaneously to the left ventricular myocardium of 18 pigs with CMI. Pigs were randomized (1:1:1) to receive adenoviral vector HGF (total ...

BACKGROUND The ability of stress radionuclide myocardial perfusion imaging to predict adverse cardiac events is well accepted. As left ventricular systolic function has also been shown to be an important prognostic indicator, the objective of this study was to determine whether electrocardiography (ECG)-gated single photon emission computed tomography (SPECT) functional data add additional powe...