To test the hypothesis that there is up-regulation of beta-adrenergic receptor density or supersensitivity of beta-adrenergic receptor-stimulated adenylate cyclase in the denervated transplanted human heart, we studied myocardium from transplanted, normal, and failing hearts. Myocardium was obtained from 10 patients 9 +/- 3 months after cardiac transplantation, from 10 patients without cardiac ...

The purpose of the study. There are investigation possibility using laser Doppler flowmetry method to assess blood microcirculation and analyze mechanisms its regulation in conditionally intact ischemic myocardium small laboratory animals (rats) identify "coronary theft" syndrome. Materials methods. experiments were carried out on white mongrel anesthetized (urethane 1300 mg/kg /b) male rats we...

reverse redistribution pattern is defined as decreased activity in the myocardium in the rest phase of the myocardial perfusion scan in comparison with the stress images. there are many studies concerning the etiology and clinical significant of this phenomenon in nuclear medicine literature. the dominant idea about etiology of reverse redistribution is early wash out of the radiotracer from th...

Epicardial adipose tissue (EAT) is a visceral depot of the heart fat, which has high plasticity and directly contact with myocardium coronary arteries. fat unique paracrine organ closely anatomically physiologically related to myocardium. Recent studies have repeatedly confirmed role epicardial in progression cardiovascular diseases. The accumulation EAT, measured by using new non-invasive imag...

Feasibility of identifying viable myocardium in rest and stress magnetic resonance imaging (MRI) was evaluated using 3 hr occlusion and 30 min reperfusion model of left anterior descending (LAD) coronary artery in 12 felines. At rest MRI, viable myocardium confirmed by 2,3,5-triphenyl tetrazolium chloride (TTC)-staining showed rapid signal intensity (SI) rise followed by gradual decline not sig...