Myocardial necrosis can be result from a number of causes including nutritional deficiencies, chemical and plant toxins, ischemia and metabolic disorder. The outcome of myocardial necrosis varies depending on the extent of the damage (Donald 2001, Jubb 1993, Radostits 1994, Vanvaleet 1986). Myocardial infarction without demonstrable of atherosclerosis were reported in a rhesus macaque (Gonder 1...

BACKGROUND Hybrid positron emission tomography and magnetic resonance allows the advantages of magnetic resonance in tissue characterizing the myocardium to be combined with the unique metabolic insights of positron emission tomography. We hypothesized that the area of reduced myocardial glucose uptake would closely match the area at risk delineated by T2 mapping in ST-segment-elevation myocard...

AIMS Ischemic preconditioning (IPC) is a potent form of endogenous protection. However, IPC-induced cardioprotective effect is significantly blunted in insulin resistance-related diseases and the underlying mechanism is unclear. This study aimed to determine the role of glucose metabolism in IPC-reduced reperfusion injury. METHODS Normal or streptozotocin (STZ)-treated diabetic rats subjected...

OBJECTIVES In this study we determined whether 13N-ammonia uptake measured late after injection provides additional insight into myocardial viability beyond its value as a myocardial blood flow tracer. BACKGROUND Myocardial accumulation of 13N-ammonia is dependent on both regional blood flow and metabolic trapping. METHODS Twenty-six patients with chronic coronary artery disease and left ve...

myocardial necrosis can be result from a number of causes including nutritional deficiencies, chemical and plant toxins, ischemia and metabolic disorder. the outcome of myocardial necrosis varies depending on the extent of the damage (donald 2001, jubb 1993, radostits 1994, vanvaleet 1986). myocardial infarction without demonstrable of atherosclerosis were reported in a rhesus macaque (gonder 1...

Under resting conditions, the failing heart shifts fuel use toward greater glucose and lower free fatty acid (FFA) oxidation. We hypothesized that chronic metabolic abnormalities in patients with dilated cardiomyopathy (DCM) are associated with the absence of the normal increase in myocardial glucose uptake and maintenance of cardiac mechanical efficiency in response to pacing stress. In 10 DCM...

BACKGROUND The presence of persistent myocardial uptake of 18F-deoxyglucose (FDG) within hypoperfused, dysfunctional segments has been shown to predict the recovery of regional contractile function after revascularization. The spectrum of metabolic responses of such hibernating tissue to revascularization is less clear. METHODS AND RESULTS Sixteen patients with previous infarction were studie...

BACKGROUND Atherosclerosis is considered to be an inflammatory disease associated with the activation of hematopoietic and immune-related organs such as the bone marrow (BM) and spleen. We evaluated the metabolic activity of those organs and of the carotid artery with (18)F-fluorodeoxyglucose positron emission tomography in patients with coronary artery disease, including acute myocardial infar...

A 57-year-old female was referred to our hospital for severe left ventricular hypertrophy (LVH). Although she had no symptoms and no history of hypertension, echocardiography demonstrated severe LVH in the mid LV to the apex with no asymmetric septal hypertrophy. Thus, we suspected apical type of HCM and performed FDG-PET/MRI. After fasting for more than 18 hours, the patient was administered u...

BACKGROUND Reduced respiratory muscle endurance (RME) contributes to increased dyspnea upon exertion in patients with cardiovascular disease. OBJECTIVE The objective was to characterize ventilatory and metabolic responses during RME tests in post-myocardial infarction patients without respiratory muscle weakness. METHOD Twenty-nine subjects were allocated into three groups: recent myocardia...