Objective(s): This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt.(CTF)against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. Materials and Methods: Left ventricular developed pressure (LVDP) and the maximum rate of rise and fall of LV pressure (±dp/dtmax) were recorded. Cardiac injury was as...

introduction: it has been reported that traumas such as transverse abdominal incision before myocardial ischemia result in a significantly decreased infarct size. this phenomenon is named remote preconditioning of trauma. since small skin burn is one of most common traumas, the effect of this injury on ischemia-induced arrhythmias and infarct size was investigated in a rat model of ischemia-rep...

BACKGROUND Effects of myocardial injury on E-selectin remain unclear. Thus, we investigated the diagnostic value of E-selectin for myocardial injury in children of no more than 14 years of age, which determined the scoring method of myocardial injury. METHODS In this prospective study, plasma E-selectin, cardiac troponin I (cTnI) and creatine kinase isoenzyme MB (CK-MB) concentrations in pedi...

Myocardial inflammation, COVID-19, and HFpEF inflammation is widely considered to be one of the main factors in development heart failure (HF). It believed that persistent myocardial plays a central role adverse left ventricular remodeling after infarction, as well pathogenesis dilated cardiomyopathy with preserved ejection fraction (HFpEF). – In May 2020, Tavazzi et al. reported first case acu...

While coronary thrombolytic therapy in clinical practice is well established for acute myocardial infarction, the injury associated with reperfusion ("reperfusion injury") is still under intense investigation regarding its nature and the strategy for its prevention. Reperfusion injury has been defined as cell injury caused by reperfusion itself, in contradistinction to cell injury caused by the...

Ischemia/reperfusion (I/R) injury is a major cause of myocardial damage. Despite continuous efforts, minimizing I/R injury still represents a great challenge in standard medical treatments of ischemic heart disease, i.e., thrombolytic therapy, primary percutaneous coronary intervention, and coronary arterial bypass grafting. Development of effective interventions and strategies to prevent or re...

AIM The elevation of troponin-T (TnT) and occurrence of transient slow-flow phenomena have been recognized as procedure-related myocardial injuries. Little is known about the characteristics of high-risk plaque resulting in myocardial injury after coronary stenting. METHODS The culprit plaques in 42 consecutive patients with stable angina undergoing elective coronary stenting were observed by...

The results obtained in the present investigations point to a definite correlation between the onset of myocardial injury, electrocardiographic changes and biochemical changes. Changes in the electrocardiogram and elevated serum levels were paralleled by an increased excretion of magnesium in urine as early as one hour. Serum calcium and serum potassium levels did not show any significant ...

In recent years, percutaneous coronary intervention (PCI) has become a well-established technique for the treatment of coronary artery disease. PCI improves symptoms in patients with coronary artery disease and it has been increasing safety of procedures. However, peri- and post-procedural myocardial injury, including angiographical slow coronary flow, microvascular embolization, and elevated l...