Objectives Cardiac biomarkers have been studied in sepsis in the past and various mechanisms for their rise have been elucidated. However their association with severity of sepsis, mortality and myocardial dysfunction warrants further studies. We have studied three different cardiac biomarkers- troponin T (trop T), creatine phosphokinase MB isoform (CPK MB) and NT pro brain natriuretic peptide ...

Myocardial ischemia (MI) resulting in infarction is an important cause of mortality and morbidity worldwide. Acute ischaemia rapidly impairs myocardial contractile function. Myocardial dysfunction persisting for several hours after transient non-lethal ischaemia, eventually resulting in full functional recovery is termed as myocardial stunning. Hibernation is now thought to be...

takotsubo cardiomypathy is a very rare cardiovascular syndrome leading to myocardial infarction and left ventricular dysfunction in the absence of a detectable coronary artery lesion. it is accepted as reversible left ventricular asynergy occuring typically after an intrinsic adrenergic hyperstimulation. in this report we present takotsubo cardiomyopathy in a 75-year-old patient with multiple a...

there are few reports concerning interferon induced myocardial dysfunction. a known case of multiple myeloma who was receiving interferon alpha (ifa) for 14 months was brought to the emergency room in frank: pulmonary edema. after treatment of heart failure and discontinuation of interferon alpha, he remained asymptomatic thereafter. another case of chronic active hepatitis on ifa complained of...

BACKGROUND The purpose of this study was to determine the relative contribution of fibrosis-mediated and myofibril-mediated stiffness in rats with mild and severe right ventricular (RV) dysfunction. METHODS AND RESULTS By performing pulmonary artery banding of different diameters for 7 weeks, mild RV dysfunction (Ø=0.6 mm) and severe RV dysfunction (Ø=0.5 mm) were induced in rats. The relativ...

Endotoxin is one of the major factors causing myocardial depression and death during sepsis in humans. Recently, it was reported that endotoxin may induce cardiomyocyte apoptosis. Also, multiple caspase activation has been implicated in endotoxin-induced apoptosis in several organ systems. In this study, we investigated whether endotoxin would increase myocardial caspase activities and evaluate...

Inflammation promotes endothelial dysfunction, but the underlying mechanisms remain poorly defined in vivo. Using translational vascular function testing myocardial infarction patients, a situation where inflammation is prevalent, and knock-out (KO) mouse models we demonstrate role for mitogen-activated-protein-kinases (MAPKs) dysfunction. Myocardial significantly lowers mitogen stress kinase 1...

Erectile dysfunction is a common problem whose relation to cardiovascular diseases has scientifically been proved, but it has not been studied sufficiently in patients recovering from myocardial infarction. The objective of this study was to establish the frequency of erectile dysfunction in patients recovering from myocardial infarction. We examined 89 patients (aged 30 to 75 years) included i...