background: neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (sci) and these cells cause substantial secondary tissue damage. the purpose of this study was to determine the effect of oleuropein (oe) on myeloperoxidase (mpo) activity as an index of neutrophil infiltration. methods: rats were randomly divided into four groups of 7 rats each as...

the adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (cad). the inflammatory enzyme, myeloperoxidase (mpo) also has an important role in the pathogenesis of cad. association of the adipokines with mpo remains to be resolved in patients with cad. in this case-control study, 100 patients with cad and 100 control subjects were appropriately r...

INTRODUCTION Histological changes of psoriasis include invasion of neutrophils into the epidermis and formation of Munro abscesses in the epidermis. Neutrophils are the predominant white blood cells in circulation when stimulated; they discharge the abundant myeloperoxidase (MPO) enzyme that uses hydrogen peroxide to oxidize chloride for killing ingested bacteria. AIM To investigate the contr...

Myeloperoxidase (MPO) activity is suggested to reduce the function of vascular nitric oxide, thereby contributing to endothelial dysfunction, although data in rodents are inconclusive. We examined vascular contractile and relaxant responses in MPO-deficient (MPO(-/-)) and wild-type mice to investigate the role for myeloperoxidase in the development of endothelial dysfunction. Carotid and saphen...

Abstract Background Inflammation and oxidative stress are thought to play an important role in the pathophysiology of HFpEF through development endothelial dysfunction. Myeloperoxidase (MPO), a leukocyte-derived enzyme, functions as link between inflammation is interesting therapeutic target. Purpose To compare MPO levels old controls define clinical characteristics associated with high MPO. Me...

A direct, rapid, quantitative colorimetric assay to determine neutrophil primary granule degranulation was adapted for use with fathead minnow kidney neutrophils. The assay measures the exocytosis of myeloperoxidase (MPO) using 3,3',5,5'-tetramethylbenzidine as a substrate. The assay was validated by comparing the total myeloperoxidase content of neutrophil populations obtained from adult cattl...

During vascular inflammation, the leukocyte-derived enzyme myeloperoxidase (MPO) is transcytosed across endothelium and into sub-endothelial extracellular matrix, where it promotes endothelial dysfunction by catalytically consuming nitric oxide (NO) produced NO synthase (eNOS). In presence of chloride ions hydrogen peroxide (H2O2), MPO forms oxidant hypochlorous acid (HOCl). Here we examined sh...

We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride i...

Thrombotic thrombocytopenic purpura (TTP) complicated with myeloperoxidase anti-neutrophil cytoplasmic autoantibody (MPO-ANCA)-associated vasculitis is rare and generally has a serious prognosis. We report a case wherein TTP was successfully treated with repeated plasma exchange (PE) and MPO-ANCA-associated vasculitis with corticosteroids. The renal function consequently improved such that haem...

Early T precursor acute lymphoblastic leukemia (ETP ALL) is rare and has a characteristic phenotype. Mixed phenotype (MPAL), as per World Health Organization, needs to have two different lineages. On cytochemistry, myeloid lineage designated by more than 3% blast cells positivity for cytochemical myeloperoxidase (MPO). Flow cytometric analysis of MPO an arbitrary cutoff 10% been described in th...