Recent mathematical models have been developed for the Acute myeloid Leukaemia and myeloproliferative disorder. In this paper system of ODE is modelled. With help model we proposed necrotic core which develops in progression disease where cell subjected to accidental death that leads inflammation.

AIMS To compare the sensitivity of the ultrastructural method to detect myeloperoxidase (MPO) with light microscopy and immunocytochemistry using an anti-MPO antibody; to examine the expression of lymphoid antigens in relation to MPO activity in blast cells from cases of biphenotypic leukaemia. METHODS Blast cells from 14 cases of biphenotypic acute leukaemia were analysed. Immunological mark...

OBJECTIVES This study aimed to assess the incidence and trend of childhood leukaemia in Basrah. METHODS This was a hospital-based cancer registry study carried out at the Pediatric Oncology Ward, Maternity & Children's Hospital and other institutes in Basrah, Iraq. All children with leukaemia, aged 0 to 14 years diagnosed and registered in Basrah from January 2004 to December 2009 were includ...

OBJECTIVES To investigate the risk of leukaemia in workers in the petroleum distribution industry who were exposed to low levels of benzene. METHODS From the cohort of distribution workers, 91 cases were identified as having leukaemia on either a death certificate or on cancer registration. These cases were compared with controls (four per case) randomly selected from the cohort, who were fro...

Fifty-three patients with chronic myeloid leukaemia (CML) were included in this study (25 females & 28 males) and followed-up from October 2003 till October 2005 included for the evidence of acute transformation. Twenty-one patients (39.6%) transformed to acute phase , 16 patients(76.1%) of them transformed during the first 4 years of diagnosis. Fifteen patients (71.4 %) ) transformed to acute ...

Promoter hypermethylation-mediated inactivation of ID4 plays a crucial role in the development of solid tumours. This study aimed to investigate ID4 methylation and its clinical relevance in myeloid malignancies. ID4 hypermethylation was associated with higher IPSS scores, but was not an independent prognostic biomarker affecting overall survival (OS) in myelodysplastic syndrome (MDS). However,...

Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117. SCF-Kit signalling is crucial for the survival, proliferation and differentiation of hematopoietic cells of myeloid lineage. Furthermore, since myeloid leukaemia cells express the Kit receptor, SCF may play an important role in myeloid leukae...

A monoclonal antibody, NP57, was produced and used against the neutrophil granule protein elastase, which selectively stain neutrophils in cryostat and paraffin wax sections. The antibody stains neutrophils and a subpopulation of monocytes in blood smears and neutrophil precursors in bone marrow smears, and gives positive reactions with the cell lines HL60 and U-937. It labelled the blast cells...

Lysosomal enzyme activities were studied in cells derived from the following types of leukaemia: chronic myeloid, acute myeloid, acute myelomonocytic, acute monocytic, non-T, non-B cell acute lymphoblastic, T-cell acute lymphoblastic, B-cell chronic lymphocytic and T-cell chronic lymphocytic. Activities of beta-hexosaminidase and alpha-mannosidase were significantly higher in cells from acute m...