نتایج جستجو برای: myc
تعداد نتایج: 16295 فیلتر نتایج به سال:
Background: Identification of targetable biology in breast cancer is an unmet need, particularly for triple negative (TNBC) where patient outcome poor and there are few clinically approved targeted therapies. Here, we identify the anion channel GPR89, to be a novel oncogene relevant TNBC other subtypes. Materials Methods: We analyzed GPR89 subcellular localization using immunofluorescence, frac...
Abstract Medulloblastoma (MB) is one of the most prevalent malignant brain tumors in children, with tremendous cognitive and neuroendocrine disability among survivors. Group 3 (G3) MBs have poor overall survival at < 50%, few recurrent mutations, higher frequency metastasis, no targeted therapies. Amplification MYC (c-myc) activation TGFβ signaling are frequent G3 MB. We hypothesize that...
The Myc oncoprotein family comprises transcription factors that control multiple cellular functions and are widely involved in oncogenesis. Here we report the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc. Myc-nick retains conserved Myc box regions but lacks nuclear localization signals and the bHLHZ domain esse...
Although N-myc amplification in neuroblastomas correlates with poor prognosis, not all neuroblastomas which fail to respond to therapy have N-myc amplification. To determine whether other modes of myc gene activation underlie progression of some neuroblastomas, 45 were analyzed for amplification of N-myc, c-myc and L-myc and 26 were studied for transcription of these oncogenes. N-myc amplificat...
Background: The differential diagnosis of Burkitt lymphoma/leukemia (BL) and the double or triple hit lymphomas remains often problematic in terms immunophenotyping association with MYC gene analysis. In past, BL-like B-cell malignancy precursor phenotype (BCP-ALL) was described. Case Report: We report here an 84-year-old male massive ascites without superficial lymphadenopathy. Abdominal parac...
The myc family of genes contains five functional members. We describe the cloning of a new member of the myc family from rat genomic and cDNA libraries, designated B-myc. A fragment of cloned B-myc was used to map the corresponding rat locus by Southern blotting of DNA prepared from rat X mouse somatic cell hybrids. B-myc mapped to rat chromosome 3. We have previously mapped the c-myc to rat ch...
We have determined the nucleotide sequence and transforming activity of the human L-myc gene and a processed L-myc pseudogene (L-myc psi). We demonstrate by cotransformation assays that a 10.6-kb EcoRI fragment derived from a human placental library contains a complete and functional L-myc gene including transcriptional regulatory sequences sufficient for expression in rat embryo fibroblasts. O...
The transcription factor MYC is a proto-oncogene regulating cell proliferation, cell cycle, apoptosis and metabolism. The recent identification of MYC-regulated long noncoding RNAs (lncRNAs) expands our knowledge of the role of lncRNAs in MYC functions. Here, we identify MYC-repressed lncRNAs named MYCLo-4, -5 and -6 by comparing 3 categories of lncRNAs (downregulated in highly MYC-expressing c...
MYC alterations influence the survival of patients with diffuse large B-cell lymphoma. Most studies have focused on MYC translocations but there is little information regarding the impact of numerical alterations and protein expression. We analyzed the genetic alterations and protein expression of MYC, BCL2, BCL6, and MALT1 in 219 cases of diffuse large B-cell lymphoma. MYC rearrangement occurr...
زمینه و هدف: بروز سرطان معده در کشورهای غربی در سال های اخیر کاهش نشان داده است، در حالی که در ایران شایع ترین سرطان در بین مردان است. ژن myc، در روی کروموزوم 8q24.1 قرار گرفته و در حدود 15% ژن های انسان را تنظیم و در 20% تمام تومورهای انسان فعال می شود. تکثیر myc و بیان بیش از حد آن در 30-15% نئوپلازی های معده مشاهده شده است. هدف از این مطالعه، بررسی برتری آزمایش cish نسبت به ihc در پیش آگهی س...
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