OBJECTIVE There is a lack of published information on the management of mumps in a prison setting. We describe an outbreak of mumps that occurred in a medium-security correctional centre (Milner Ridge) in Manitoba, Canada. METHODS A case definition of mumps consistent with that in the document "Guidelines for the Prevention and Control of Mumps Outbreaks in Canada" was adopted. Cell culture, ...

Total immunoglobulin G (IgG) and IgG subclass reactivities with purified mumps glycoproteins (GP) and nucleoprotein (NP), measured in enzyme-linked immunosorbent assays (ELISAs), were compared with titers in a mumps microneqtralization assay (NT). For determination of mumps immunity, the sensitivity of both ELISAs was 100% in comparison with the NT and the specificity was 90%. IgGl was the domi...

UNLABELLED In early 1997 an unexpectedly high number of cases of mumps was reported in Vancouver, British Columbia. METHODS A case control study was conducted to address four objectives: 1) Describe the outbreak and the population at risk, 2) examine the impact of mumps on this population, 3) identify personal risk factors for infection, and 4) test the hypothesis that social gatherings, 'rav...

In the last decade, several mumps outbreaks were reported in various countries despite high vaccination coverage. In most cases, young adults were affected who have acquired immunity against mumps solely by vaccination and not by previous wild-type mumps virus infection. To investigate mumps-specific antibody levels, functionality and dynamics during a mumps epidemic, blood samples were obtaine...

CONTEXT Acute pancreatitis is a complication of mumps which mainly affects children who then usually acquire permanent immunity. We present the case of a woman with acute pancreatitis caused by mumps re-infection in adulthood. CASE REPORT A 34-year-old woman developed mild acute pancreatitis caused by re-infection with mumps, as confirmed serologically by enzyme-linked immunosorbent assays mu...

Mumps virus infection is normally diagnosed by serologic testing. Identification of mumps-specific IgM antibodies in serum or plasma by enzyme immunoassay analysis (EIA) in samples taken during the acute phase is the most-widely used serologic test for the diagnosis of mumps, due to its simplicity, high sensitivity and specificity. When the infection cannot be confirmed by serologic tests, the ...

Mumps is a potentially severe viral infection. The incidence of mumps has declined dramatically in high-income countries since the introduction of mumps antigen-containing vaccines. However, recent large outbreaks of mumps in highly vaccinated populations suggest waning of vaccine-induced immunity and primary vaccine failure. In this paper we present a simple method for identifying geographic r...

Although mumps vaccines have been used for several decades, protective immune correlates have not been defined. Recently, mumps outbreaks have occurred in vaccinated populations. To better understand the causes of the outbreaks and to develop means to control outbreaks in mumps vaccine immunized populations, defining protective immune correlates will be critical. Unfortunately, no small animal ...

The mumps virus belongs to the family of paramyxoviruses. It has a single-strand, nonsegmented, negative-sense RNA genome and is spread by the respiratory route. Following a 12–25-day incubation period, infection frequently causes the classic symptom of mumps: painfully swollen parotid salivary glands (parotitis). Some complications of infection include hearing loss, orchitis, oophoritis, masti...