Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to ...

objective: average age of population in the industrial countries has increased. because of aging the percent of the diseases related to the oldness such as multiple myeloma have also increased. it has both common and unique symptoms and effects. the unique effects include wide bone reabsorption. it seems necessary to understand the structure of bone marrow niche and the effects of myeloma cells...

chronic myelogenous leukemia (cml) is a stem cell disorder sometimes associated with lymphoproliferative disorders. cml may precede a lymphoproliferative disorder. there are a few reports showing associating of cml with multiple myeloma and we report a known cml case that transformed into a full-blown multiple myeloma. this patient had more than 69% of infiltrating myeloma cells in her bone mar...

plasmacytoma are extramedullary accumulations of plasma cells. most extramedullary plasmacytomas are associated with the upper respiratory tract. the lung is rarely involved. we report a rare case of lung plasmacytoma with multiple myeloma. the patient is a 60-year-old male who presented with chest pain and a lung mass visualized on ct scan. a preliminary diagnosis of occult lung cancer with wi...

igd myeloma is very rate. it differs from multiple myeloma of other classes in several aspects and its laboratory diagnosis may be difficult, as total plasma protein concentration is often normal, and a paraprotein peak may not be easily demonstrable by the conventional electrophoretic techniques. we report here two cases of igd myeloma investigated in this laboratory. immunochemical, biochemic...

. frequent macroscopic hematuria in multiple myeloma is quite rare and exceptional and no report has been found in the literature. we have presented a case of multiple myeloma who developed frequent episodes of gross hematuria during her long lasting but slowly progressing course of the disease

recent evidences suggest that multiple myeloma phenotypes (mmps) are involved in the infiltration of multiple myeloma-affected marrow foci. in this study, the effects of arsenic trioxide on the invasive and angiogenic phenotypes of multiple myeloma (mm) cell line were assessed on a dose-response and time-course basis. multiple myeloma cell line, karpas 707, was treated with step-wise elevated c...