نتایج جستجو برای: mullerian inhibiting substance

تعداد نتایج: 267258  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Grégoy Y Bédécarrats Francis H O'Neill Errol R Norwitz Ursula B Kaiser Jose Teixeira

In addition to its role in causing Müllerian duct regression, Müllerian inhibiting substance (MIS) is implicated in the regulation of steroidogenesis, breast and prostate growth, and ovarian follicle recruitment, all of which are processes controlled or influenced by the hypothalamic-pituitary-gonadal axis. Whereas the direct effect of MIS on gonadal, prostate, and breast cells is under investi...

Journal: :Endocrine reviews 1993
M M Lee P K Donahoe

Mullerian inhibiting substance (MIS) is the gonadal hormone that causes regression of the Mullerian ducts, the anlagen of the female internal reproductive structures, during male embryogenesis. MIS is a member of the large transforming growth factor-beta (TGF beta) multigene family of glycoproteins that are involved in the regulation of growth and differentiation. The proteins in this gene fami...

2013
Yih Harng Chong Nicola A. Dennis Martin J. Connolly Ruth Teh Gregory T. Jones Andre M. van Rij Stephanie Farrand A. John Campbell Ian S. MLennan

The Sertoli cells of the testes secrete anti-Müllerian hormone (Müllerian inhibiting Substance, AMH) and inhibin B (InhB). AMH triggers the degeneration of the uterine precursor in male embryos, whereas InhB is part of the gonadal-pituitary axis for the regulation of sperm production in adults. However, both hormones are also putative regulators of homeostasis, and age-related changes in these ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Thanh U Barbie David A Barbie David T MacLaughlin Shyamala Maheswaran Patricia K Donahoe

In addition to causing regression of the Mullerian duct in the male embryo, Mullerian Inhibiting Substance (MIS) inhibits the growth of epithelial ovarian cancer cells, which are known to be of Mullerian origin. Because the uterine cervix is derived from the same Mullerian duct precursor as the epithelium of the ovary, we tested the hypothesis that cervical cancer cells might also respond to MI...

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