Background: Sleep disorder, frequently observed among perimenopausal women, decreases quality of life. Melatonin is reported to ameliorate circadian imbalances and thus can be employed as a treatment for sleep disorder patients. We attempted clarify whether how melatonin affects disorders. Methods: Study patients consisted 120 women divided into 3 groups: (i) without (n = 60); (ii) those with b...

This study aimed to investigate whether a specific genotype of the MTNR1A gene influences social dominance and reproductive performance in rams. Thirty-one rams were genotyped for Rsal Mnll polymorphism gene: CC (n=19), CT (n=5), TT (n=7), GG (n=20), GA (n=6), or AA respectively. Maintenance (standing still, lying down, drinking, feeding, walking, stereotyping) behavior (agonistic antagonistic ...

Remarkable seasonal variations are observed in the reproductive activities of small ruminants living in temperate latitudes (Luridiana et al. 2015). Thus, a great alteration is induced by lamb reproductive seasonality and its consequent meat market price. Alternatively, out-of-season reproduction is induced through a wide use of hormonal treatments in some countries. However, there is a need fo...

We report on a 12-year-old boy who presented with delayed development and CNS dysmyelination. Genetic studies showed a normal 46,XY karyotype by routine cytogenetic analysis, and 46,XY.ish del(18)(q23)(D18Z1+, MBP-) by FISH using a locus-specific probe for the MBP gene (18q23). Though the patient appeared to have normal chromosome 18s by repeated high resolution banding analysis, his clinical f...

Melatonin receptor 1A gene is the prime receptor mediating the effect of melatonin at the neuroendocrine level for control of seasonal reproduction in sheep. The aims of this study were to examine the polymorphism pattern of coding sequence of MTNR1A gene in Chokla sheep, a breed of Indian arid tract and to identify new variations in relation to its aseasonal status. Genomic DNAs of 101 Chokla ...

background : the main function of the pineal hormone melatonin which is mediated via its two receptors, mtnr1a and mtnr1b, is to mediate dark signals in addition to anti-oxidation, immune system enhancement, protection from radiation, and anti-cancer functions. a common single nucleotide polymorphism in the mtnr1b gene is rs#10830963, which is well known as a risk factor for type 2 diabetes mel...

Epidemiologic and animal studies indicate that disruption of circadian rhythm increases breast cancer risk. Previously, we showed that methylselenocysteine reduced the incidence of N-nitroso-N-methylurea (NMU)-induced mammary carcinomas in Fischer 344 rats by 63%. Methylselenocysteine also increased the expression of Period 2 (Per2) and D-binding protein (DBP), providing evidence for a link bet...