نتایج جستجو برای: msa model
تعداد نتایج: 2106435 فیلتر نتایج به سال:
A generalization of Profile Hidden Markov Model (PHMM) using one-by-one dependency between sequences
The Profile Hidden Markov Model (PHMM) can be poor at capturing dependency between observations because of the statistical assumptions it makes. To overcome this limitation, the dependency between residues in a multiple sequence alignment (MSA) which is the representative of a PHMM can be combined with the PHMM. Based on the fact that sequences appearing in the final MSA are written based on th...
Clinical criteria, microsatellite analysis (MSA) and immunohistochemistry (IHC) are important diagnostic tools for identification of hereditary nonpolyposis colorectal cancer (HNPCC) patients who are likely to carry pathogenic germline mutations in mismatch repair genes. Based on MSA and IHC results and subsequent mutation analyses of 1,119 unrelated index patients meeting the Amsterdam II crit...
Biodiversity in rangelands is decreasing, due to intense utilization for livestock production and conversion of rangeland into cropland; yet the outlook of rangeland biodiversity has not been considered in view of future global demand for food. Here we assess the impact of future livestock production on the global rangelands area and their biodiversity. First we formalized existing knowledge ab...
Background. Patients with multiple system atrophy (MSA), similarly to patients with alpha-synucleinopathies, can present with different sleep problems. We sought to analyze sleep problems in the two subtypes of the disease MSA cerebellar type (MSA-C) and MSA parkinsonian type (MSA-P), paying special attention to REM sleep disturbances and periodic limb movements (PLMs). Methods. In the study we...
The Babesia bovis merozoite surface antigen 2 (MSA-2) locus encodes four proteins, MSA-2a(1), -2a(2), -2b, and -2c. With the use of specific antibodies, each MSA-2 protein was shown to be expressed on the surface of live extracellular merozoites and coexpression on single merozoites was confirmed. Individual antisera against MSA-2a, MSA-2b, and MSA-2c significantly inhibited merozoite invasion ...
We give a short summary of the fixed-energy Multi-Scale Analysis (MSA) of the Anderson tight binding model in dimension d ≥ 1 and show that this technique admits a straightforward extension to multi-particle systems. We hope that this short note may serve as an elementary introduction to the MSA.
The purposes of this report is to describe the distribution of reported negative mood by place of residence focusing on proximity to metropolitan statistical areas (MSA's) as an alternative to the traditional urban versus rural residence variable using the 1991 National Health Interview Survey's Health Promotion and Disease Prevention (NHIS-HPDP) supplement. The self-report of negative mood com...
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder characterized by various combinations of autonomic dysfunction, cerbellar symptoms, parkinsonism and pyramidal signs. Although molecular mechanisms of MSA remain to be elucidated, genome-wide association studies (GWAS) may provide clues as to the susceptibility genes for MSA. Establishment of the natural history of MSA is es...
This paper discusses a novel probabilistic synchronous TAG formalism, synchronous Tree Substitution Grammar with sister adjunction (TSG+SA). We use it to parse a language for which there is no training data, by leveraging off a second, related language for which there is abundant training data. The grammar for the resource-rich side is automatically extracted from a treebank; the grammar on the...
BACKGROUND Brain magnetic resonance (MR) imaging offers the potential for objective criteria in the differential diagnosis of multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson disease (PD), since it frequently shows characteristic abnormalities in patients with MSA-P and is believed to be normal in patients with PD. OBJECTIVE To determine concordance between clinical...
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