Most of the previous efforts on enhancing the DT-MRI estimation/smoothing have been based on “what is assumed to be correct”; and there are only very few studies concentrating on the validation of these approaches. This project presents our current efforts and observations for a validation framework. In the scope of this framework, high resolution fluoroscopy slices obtained from the brain stem...

BACKGROUND The aim of this study was the assessment of kidney morphology and glomerular filtration rate (GFR) in rat models of polycystic kidney disease and a healthy control group of Sprague-Dawley rats (SD rats). The performance of two non-invasive GFR estimation methods-3.0 Tesla magnetic resonance imaging (MRI) and optical imaging were investigated. Data of GFR assessment was compared to su...

Human studies have established that adolescence is a period of brain maturation that parallels the development of adult behaviors. However, little is known regarding cortical development in the adult rat brain. We used magnetic resonance imaging (MRI) and histology to assess the impact of age on adult Wistar rat cortical thickness on postnatal day (P)80 and P220 as well as the effect of adolesc...

BACKGROUND Dodecafluoropentane emulsion (DDFPe), an oxygen transport agent, has been shown to reduce infarct volume in animal models of acute ischemic stroke (AIS). Our study assesses the effect of DDFPe on MRI markers of infarct evolution in the early hours after vascular occlusion in a rat AIS model. We hypothesized that DDFPe will delay the development of MRI markers of AIS and/or reduce the...

Appropriately sized arteries in small animals may be possible models for studying the remodeling process as occurs after arterial balloon injury in humans. Magnetic resonance imaging (MRI) is able to noninvasively image tissue in vivo. To date, small animal angiography models have mostly used research-dedicated instruments and resolution, which are not universally available. Experiments were ca...

This data article describes a large, high resolution diffusion MRI data set from fixed rat brain acquired at high field strength. The rat brain samples consist of 21 adult rat brain hemispheres from animals exposed to chronic mild stress (anhedonic and resilient) and controls. Histology from amygdala of the same brain hemispheres is also included with three different stains: DiI and Hoechst sta...

We introduce an automatic 3D multiscale automatic segmentation algorithm for delineating specific organs in Magnetic Resonance images (MRI). The algorithm can process several modalities simultaneously, and handle both isotropic and anisotropic data in only linear time complexity. It produces a hierarchical decomposition of MRI scans. During this segmentation process a rich set of features descr...

H. Cheng, D. E. Olson, Y. Liu, P. M. Thule, M. T. Pardue, T. Q. Duong Yerkes Imaging Center, Emory University, Atlanta, GA, United States, School of medicine, Emory University, Atlanta, GA, United States, Atlanta VA Medical Center, Atlanta, GA, United States, Department of Ophthalmology, Emory University, Atlanta, GA, United States Introduction Diabetic retinopathy (DR) is a leading cause of bl...