نتایج جستجو برای: mpeg b pcl

تعداد نتایج: 910360  

2010
Nguyen-Van Cuong Jian-Lin Jiang Yu-Lun Li Jim-Ray Chen Shyh-Chuan Jwo Ming-Fa Hsieh

The triblock copolymer is composed of two identical hydrophilic segments: Monomethoxy poly(ethylene glycol) (mPEG) and one hydrophobic segment poly(ε‑caprolactone) (PCL); which is synthesized by coupling of mPEG-PCL-OH and mPEG‑COOH in a mild condition using dicyclohexylcarbodiimide and 4-dimethylamino pyridine. The amphiphilic block copolymer can self-assemble into nanoscopic micelles to accom...

Journal: :Micromachines 2023

The administration of poorly water-soluble drugs represents a relevant problem due to the low body fluids transport efficiency through hydrophilic hydrogels. Star-shaped co-polymers, i.e., amphiphilic polymers such as those with hydrophobic core and outer shell, can be used improve weak interactions drugs, benefits in terms controlled delivery. In this work, two different four-arm star-shaped P...

2016
Ming-Shan Kao Yanhan Wang Shinta Marito Stephen Huang Wan-Zhen Lin Jon A Gangoiti Bruce A Barshop Choi Hyun Woan-Ruah Lee James A Sanford Richard L Gallo Yuping Ran Wan-Tzu Chen Chun-Jen Huang Ming-Fa Hsieh Chun-Ming Huang

Many human skin diseases, such as seborrheic dermatitis, potentially occur due to the over-growth of fungi. It remains a challenge to develop fungicides with a lower risk of generating resistant fungi and non-specifically killing commensal microbes. Our probiotic approaches using a selective fermentation initiator of skin commensal bacteria, fermentation metabolites or their derivatives provide...

2012
Shuai Shi Xuechen Zhu QingFa Guo Yingjing Wang Tao Zuo Feng Luo Zhiyong Qian

BACKGROUND In this paper, a series of amphiphilic triblock copolymers based on polyethylene glycol-poly ɛ-caprolactone-polyethylenimine (mPEG-PCL-g-PEI) were successfully synthesized, and their application for codelivery of chemotherapeutic drugs and DNA simultaneously was investigated. METHODS AND RESULTS These copolymers could self-assemble into micelles with positive charges. The size and ...

Journal: :Drug Development and Industrial Pharmacy 2021

A type of multi-sensitive ABC-CBA block copolymer with thermal, glutathione and pH-responsive bonds was synthesized via ring opening polymerization along cationic mechanisms. In continuum, the strands self-assembled into nanomicelles. The linear is comprised poly (methoxy ethylene glycol)-b-poly (2-ethyl-2-oxazoline)-b-poly (?-caprolactone)-cystamine (i.e. [mPEG-b-PEtOz-PCL]2-Cys) curcumin enca...

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