Whether human infants perceive televised stimuli in the same way to live stimuli largely remains unknown. Action observation, which has been extensively confirmed to elicit activation of internal motor representation, provides a promising framework for investigating this issue. This 'mirror-matching' property has been found in the monkey premotor cortex as well as the premotor and primary motor...

BACKGROUND AND PURPOSE Recovery from stroke is hypothesized to involve the reorganization of surviving cortical areas. To study the functional organization of sensorimotor cortex at multiple time points before and after stroke, we performed longitudinal light-based motor mapping of transgenic mice expressing light-sensitive channelrhodopsin-2 in layer 5 cortical neurons. METHODS Pulses of lig...

To understand the connectivity of cerebral cortex, especially the spatial and temporal pattern of movement, functional magnetic resonance imaging (fMRI) during subjects performing finger key presses was used to extract functional networks and then investigated their characteristics. Motor cortex networks were constructed with activation areas obtained with statistical analysis as vertexes and c...

The role of protein synthesis in memory consolidation is well established for hippocampus-dependent learning and synaptic plasticity. Whether protein synthesis is required for motor skill learning is unknown. We hypothesized that skill learning is interrupted by protein synthesis inhibition (PSI). We intended to test whether local protein synthesis in motor cortex or cerebellum is required duri...