The objective of this study was to identify possible changes in mRNA and protein expression of high-mobility group box protein 1 (HMGB1) and its suggested receptors - receptor for advanced glycation end-products (RAGE) and Toll-like receptor 2 (TLR2) and TLR4 - in human cervix during pregnancy, term and preterm labor. Cervical biopsies were taken from 58 women: 20 at preterm labor, 24 at term l...

background: spontaneous preterm labor is one of the common obstetrics problems causing several physical, psychological and economical outcomes. although due to these outcomes and the efficacy of cares for decreasing them, preterm labor screening is cost-effective and it is still one of the challenging issues in obstetrics. objective: in this study preterm labor screening by using cervical trans...

background: preterm labor (ptl) is one of the most important causes in neonatal mortality and morbidity. late preterm labor (34-36w) includes 75% of such birth. assisted reproductive technology (art) pregnant women are at increased risk of ptl. objective: the study has been undertaken to determine whether beginning and continuing 17-α hydroxy progesterone caproate can reduce risk of ptl or chan...

background: there are situations in every woman’s life that impressively affect her whole life. pregnancy is one of those situations. pregnancy period is usually accompanied with positive emotions for the women and their families. sometimes depression during pregnancy disturbs daily activities, acceptance of new roles, pregnant woman´s life responsibilities and pregnancy consequences. the goal ...

OBJECTIVE This study aims to assess the success rate of inhibiting preterm uterine contraction with tocolytic agents to delay delivery for at least 48 hours and risk factors of failure inhibition. MATERIALS AND METHODS Between January 2013 and July 2014, medical records of all singleton pregnant women between 24 0/7 and 33 6/7 weeks of gestation with the diagnosis of preterm labor (with cervi...

BACKGROUND As the second paper in a two-part series on preterm labor, this article discusses the management of preterm labor as it relates to risk reduction, tocolytic therapy, corticosteroids, and antibiotics. METHODS Published literature on the management of preterm labor was reviewed by searching MEDLINE files from 1983 to the present, using the terms "preterm labor," "premature labor," "p...

OBJECTIVE Preterm labor is one of the common causes of prenatal morbidity and mortality. With considering the importance of preterm labor and lack of sufficient studies about the relationship between preterm labor and some factors such as cigarette smoking and opiate-using, the present study was designed. METHODS We performed this descriptive-analytic study on 988 pregnant women referring to ...

objective: threatened miscarriage is a common complication in pregnancy that leads to adverse pregnancy outcomes such as preterm labor. this study aimed to compare the vaginal progesterone (cyclogest) versus 17-alpha-hydroxyprogesterone caproate (proluton) on preventing preterm labor in pregnant women with threatened abortion at less than 34 weeks’ gestational age. materials and methods: this b...