OBJECTIVE To assess the outcome on management recommendations of a comparative approach vs a morphologic approach in evaluating dermoscopic images of lesions from a series of patients with multiple nevi. DESIGN In a 2-step study, 6 experienced dermoscopists were asked to provide management recommendations (excision or follow-up) for a series of lesions from patients with multiple nevi based o...

The aim was to clarify whether enhancement effects of the liver parenchyma in the hepatobiliary phase (HP) of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging were correlated with the morphological grading of the severity in cirrhosis. A total of 62 patients with chronic hepatitis or cirrhosis underwent Gd-EOB-DTPA-enhanced MR imaging. Relative enhan...

BACKGROUND AND PURPOSE Gray matter heterotopia have been divided into three groups based on clinical and imaging characteristics: subependymal, subcortical, and band heterotopia. Nonetheless, subcortical heterotopia can have variable morphologic findings. The purpose of this study was to perform a morphologic analysis of a series of cases of subcortical heterotopia based on MR images, to correl...

The World Health Organization (WHO) classification of hematopoietic neoplasms, published in 2001, included the new category of “Myelodysplastic/ Myeloproliferative Diseases,” intended to accommodate those myeloid neoplasms that simultaneously showed features of chronic myeloproliferative disorders and myelodysplastic syndromes. Typically, myelodysplastic syndromes (MDS) are clonal neoplastic di...

Morphologic changes in cortex and white matter of the cerebral frontal lobes in vascular dementia were studied. The signs of leykoaraiosis in white matter were revealed. Obvious signs of neurodegeneration expressed in loss of neurons, which is considered to be the attribute of aging process and may be one of significant etiologic factors of vascular dementia, had not been identified.

Rats were administered 24 mg/kg of paraquat intraperitoneally. One, two, three, six and seven days after this injection, the rats were evaluated by several toxicologic, biochemical, and morphologic criteria. These included determinations of weight loss, visible lung hemorrhage, pulmonary edema, in vitro protein and collagen biosynthesis rates of lung tissue, and staining properties of lung sect...

I NTENSE INTEREST EXPRESSED BY CLINIcians, physiologists, and pathologists in pulmonary emphysema has stimulated the need for establishing some criteria for the normal anatomy and subsequent pathologic change. Regardless of the conflict in the theories of etiology, we must be cognizant of certain changes which take place in the pulmonary parenchyma. The fine relationships between structure, fun...

● Context.—Glioblastoma (GBM), the most common primary intracranial malignancy, is a morphologically diverse neoplasm with dismal prognosis despite multimodality therapy. Only 3 distinct morphologic variants of GBM are currently recognized by the current World Health Organization classification scheme, including GBM, giant cell GBM, and gliosarcoma. Additional variants, some of which have signi...

• Vol 7 • December 2005 768 A key question for understanding chronic inflammatory and autoimmune diseases is where the disease actually begins. Wegener’s granulomatosis is a potentially life-threatening chronic inflammatory disease of as yet unknown etiology, characterized by granuloma formation, vasculitis, and an autoimmune response to “Wegener’s autoantigen“ proteinase 3, a 29 kD neutrophila...